Optimizing Unrelated Donor Cord Blood Transplantation

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Presentation transcript:

Optimizing Unrelated Donor Cord Blood Transplantation Juliet N. Barker, Vanderson Rocha, Andromachi Scaradavou Biology of Blood and Marrow Transplantation Volume 15, Issue 1, Pages 154-161 (January 2009) DOI: 10.1016/j.bbmt.2008.10.020 Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 A schema representing the relationships between current CB banks. The banks contained within the intersecting circles will be searched by virtue of performing a search of the National Marrow Donor Program (NMDP), Netcord, and the NMDP Cooperative Registries (“Cooperative”), respectively. The black rectangle represents the banks that can be seen by performing a search of bone marrow donors worldwide (BMDW). Units in Swedcord and AsiaCORD were not listed in BMDW as of 4/08. The schema represents the complexity of CB searches. Creating a centralized search mechanism so that the global CB inventory can be easily accessed by transplant centers should be a priority. Reproduced with permission from Mary Halet, NMDP (updated as of April 2008). Biology of Blood and Marrow Transplantation 2009 15, 154-161DOI: (10.1016/j.bbmt.2008.10.020) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Association between prior chemotherapy exposure and sustained donor engraftment after non-myeloablative CBT. University of Minnesota data. Biology of Blood and Marrow Transplantation 2009 15, 154-161DOI: (10.1016/j.bbmt.2008.10.020) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Unrelated CBT according to recipient age and year reported to Eurocord. Biology of Blood and Marrow Transplantation 2009 15, 154-161DOI: (10.1016/j.bbmt.2008.10.020) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 Transplant-related mortality in 925 CBT recipients with malignant diseases according to infused TNC Dose (×107/kg) and HLA disparity. Biology of Blood and Marrow Transplantation 2009 15, 154-161DOI: (10.1016/j.bbmt.2008.10.020) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions