The Common and Distinct Features of Brown and Beige Adipocytes

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The Common and Distinct Features of Brown and Beige Adipocytes Kenji Ikeda, Pema Maretich, Shingo Kajimura Trends in Endocrinology & Metabolism Volume 29, Issue 3, Pages 191-200 (March 2018) DOI: 10.1016/j.tem.2018.01.001 Copyright © 2018 The Author(s) Terms and Conditions

Figure 1 Anatomical Locations of Thermogenic Fat in Mice and Humans. Classical brown adipocytes reside in dedicated brown adipose tissue (BAT) depots, including interscapular, axillary, and perirenal BAT depots in mice and infants. Beige adipocytes sporadically reside in subcutaneous white adipose tissue (WAT) depots, such as the inguinal and anterior subcutaneous WAT in mice (arrowheads indicate the multilocular beige adipocytes). In adult humans, BAT is present in multiple locations, including cervical, supraclavicular, axillary, paravertebral, and abdominal subcutaneous regions. UCP1-positive adipocytes from the supraclavicular region show a molecular signature resembling that of mouse beige adipocytes, whereas the deep neck regions contain thermogenic fat that resembles classical brown adipocytes in mice. Trends in Endocrinology & Metabolism 2018 29, 191-200DOI: (10.1016/j.tem.2018.01.001) Copyright © 2018 The Author(s) Terms and Conditions

Figure 2 Developmental Lineages of Thermogenic Adipocytes. Classical brown adipocytes differentiate during embryonic development from a subset of dermomytomal precursors that express En1, Myf5, and Pax7. The development of beige adipocytes in subcutaneous WAT depots is stimulated by both environmental and endogenous stimuli, including chronic cold acclimation, exercise, PPARγ ligands, tissue injury, and cancer cachexia. When the external stimuli are withdrawn, the recruited beige adipocytes directly acquire a white fat phenotype with unilocular lipid droplets and no UCP1 expression. Trends in Endocrinology & Metabolism 2018 29, 191-200DOI: (10.1016/j.tem.2018.01.001) Copyright © 2018 The Author(s) Terms and Conditions

Figure 3 The Anti-Obesity and Anti-Diabetic Actions of Beige Fat Are UCP1-Independent. Adipose tissue-selective PRDM16 transgenic (Prdm16 Tg) mice are protected from diet-induced obesity and glucose intolerance (see phenotypes on the right). When crossed into the Ucp1−/− background, many of the metabolic phenotypes in the wild-type background are preserved in Prdm16 Tg×Ucp1−/− mice [63]. Trends in Endocrinology & Metabolism 2018 29, 191-200DOI: (10.1016/j.tem.2018.01.001) Copyright © 2018 The Author(s) Terms and Conditions