Polymorphism in the gene regulatory region of MCP-1 is associated with asthma susceptibility and severity Csaba Szalai, PhD, Gergely T. Kozma, BSc, Adrienne.

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Presentation transcript:

Polymorphism in the gene regulatory region of MCP-1 is associated with asthma susceptibility and severity Csaba Szalai, PhD, Gergely T. Kozma, BSc, Adrienne Nagy, MD, Ágnes Bojszkó, MD, Dóra Krikovszky, MD, Teréz Szabó, MD PhD, András Falus, PhD, DSc Journal of Allergy and Clinical Immunology Volume 108, Issue 3, Pages 375-381 (September 2001) DOI: 10.1067/mai.2001.117930 Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 1 Distribution of asthmatic children with different severity scores according to their genotypes at –2518 of the MCP-1 gene regulatory region. Each column represents the percent of subjects having the given genotype. Journal of Allergy and Clinical Immunology 2001 108, 375-381DOI: (10.1067/mai.2001.117930) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 2 A, Means of blood eosinophil counts in the different asthma severity groups. There are significant differences between the intermittent and moderate asthma groups (P = .003 ). B, Means of blood eosinophil counts in the different asthma severity groups with a given genotype at –2518 of the MCP-1 gene regulatory region. The differences are significant (P < .05) between subjects with A/A vs G/G and A/G vs G/G in the seasonal, mild, and moderate groups. Numbers of subjects in the subgroups were as follows: intermittent: AA, 21; AG, 10; GG, 1; seasonal: AA, 11; AG, 9; GG, 2; mild: AA, 30; AG, 39; GG, 5; moderate: AA, 6; AG, 16; GG, 10. Journal of Allergy and Clinical Immunology 2001 108, 375-381DOI: (10.1067/mai.2001.117930) Copyright © 2001 Mosby, Inc. Terms and Conditions