Volume 123, Issue 5, Pages (November 2002)

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Volume 123, Issue 5, Pages 1478-1484 (November 2002) Prognostic significance of calcium-binding protein S100A4 in colorectal cancer Silvia Gongoll, Gerrit Peters, Michael Mengel, Pompiliu Piso, Jürgen Klempnauer, Hans Kreipe, Reinhard von Wasielewski Gastroenterology Volume 123, Issue 5, Pages 1478-1484 (November 2002) DOI: 10.1053/gast.2002.36606 Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 1 Immunohistochemical staining showing S100A4 expression. (A) S100A4-negative CRC; stromal cells, e.g., fibroblasts and lymphocytes, show physiologic S100A4 expression. (B) S100A4-high positive CRC. (C) Overview of stained slide of multisampled tissue block. Gastroenterology 2002 123, 1478-1484DOI: (10.1053/gast.2002.36606) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 2 Kaplan–Meier overall survival curves for 709 patients with colorectal carcinomas grouped according to their S100A4 expression. (a) S100A4-negative cases (n = 372). (b) S100A4-low positive cases (n = 223). (c) S100A4-high positive cases (n = 114). Test statistics: log-rank test (2 degrees of freedom [df]), P < 0.0001; Wilcoxon statistic (2 df), P < 0.0001. Gastroenterology 2002 123, 1478-1484DOI: (10.1053/gast.2002.36606) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 3 Kaplan–Meier overall survival curves for 490 patients with pN0 staged carcinomas grouped according to their S100A4 expression. (a) S100A4-negative cases (n = 265). (b) S100A4-low positive cases (n = 155). (c) S100A4-high positive cases (n = 70). Test statistics: log-rank test (2 df), P = 0.0015; Wilcoxon statistics (2 df), P = 0.0008. Gastroenterology 2002 123, 1478-1484DOI: (10.1053/gast.2002.36606) Copyright © 2002 American Gastroenterological Association Terms and Conditions