Early Embryos Reprogram DNA Methylation in Two Steps

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Early Embryos Reprogram DNA Methylation in Two Steps Hao Wu, Yi Zhang Cell Stem Cell Volume 10, Issue 5, Pages 487-489 (May 2012) DOI: 10.1016/j.stem.2012.04.012 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 DNA Methylation Dynamics during Mouse Preimplantation Development (A) Methylation dynamics revealed by immunostaining. Tet3 is expressed and localized to paternal pronucleus in zygote to mediate oxidation of 5mC to 5hmC/5fC/5caC. The 5mC oxidation derivatives undergo replication-dependent dilution during preimplantation development, while the 5mC in the maternal genome follows the same dilution process without going through the oxidation process. (B) Methylation dynamics revealed by RRBS. Shown is the 5mC level of 74 CpG sites within sperm-specific DMRs (blue and red) as well as the average of all CpGs (broken lines). (Figure credit: Shinpei Yamaguchi.) Cell Stem Cell 2012 10, 487-489DOI: (10.1016/j.stem.2012.04.012) Copyright © 2012 Elsevier Inc. Terms and Conditions