Volume 25, Issue 4, Pages (December 2018)

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Volume 25, Issue 4, Pages 365-371 (December 2018) Catechin, quercetin and taxifolin improve redox and biochemical imbalances in rotenone-induced hepatocellular dysfunction: Relevance for therapy in pesticide- induced liver toxicity? Afolabi C. Akinmoladun, Comfort Odunayo Oladejo, Sunday Solomon Josiah, Courage Dele Famusiwa, Olubukola Benedicta Ojo, M. Tolulope Olaleye Pathophysiology Volume 25, Issue 4, Pages 365-371 (December 2018) DOI: 10.1016/j.pathophys.2018.07.002 Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 1 Effect of catechin, quercetin and taxifolin post-treatment on hepatic oxidative stress markers in rats subjected to rotenone toxicity. (A) Extent of lipid peroxidation, (B) Protein carbonyl content, (C) Xanthine oxidase activity, (D) Glutathione level, (E) Glutathione transferase activity, (F) Ferric reducing antioxidant power, (G) Superoxide dismutase activity, and (H) Myeloperoxidase activity. Results are expressed as mean ± SD (n = 12). ####p < 0.0001vs control; ****p < 0.0001vs rotenone. ROT: Rotenone; CAT: Catechin; QUE: Quercetin; TAX: Taxifolin. Pathophysiology 2018 25, 365-371DOI: (10.1016/j.pathophys.2018.07.002) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 2 Effects of catechin, quercetin and taxifolin post-treatment on lactate dehydrogenase activity in liver of rats subjected to rotenone toxicity. Results are expressed as mean ± SD (n = 12). ####p < 0.0001vs control; ****p < 0.0001vs rotenone. ROT: Rotenone; CAT: Catechin; QUE: Quercetin; TAX: Taxifolin. Pathophysiology 2018 25, 365-371DOI: (10.1016/j.pathophys.2018.07.002) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 3 Chemical structures of catechin, quercetin and taxifolin. Pathophysiology 2018 25, 365-371DOI: (10.1016/j.pathophys.2018.07.002) Copyright © 2018 Elsevier B.V. Terms and Conditions