Glutathione improves the function of porcine pulmonary grafts stored for twenty-four hours in low-potassium dextran solution Sebastian-P. Sommer, MD,

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Presentation transcript:

Glutathione improves the function of porcine pulmonary grafts stored for twenty-four hours in low-potassium dextran solution Sebastian-P. Sommer, MD, Bernhard Gohrbandt, MD, Stefan Fischer, MD, MSc, Jens M. Hohlfeld, MD, Gregor Warnecke, MD, Murat Avsar, MD, Martin Strüber, MD The Journal of Thoracic and Cardiovascular Surgery Volume 130, Issue 3, Pages 864-869 (September 2005) DOI: 10.1016/j.jtcvs.2005.05.021 Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Po2/Fio2 ratio in arterial blood samples drawn from the left atrium over the 7-hour reperfusion period. LPD, Low-potassium dextran; GSH, glutathione. The Journal of Thoracic and Cardiovascular Surgery 2005 130, 864-869DOI: (10.1016/j.jtcvs.2005.05.021) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 PVR over 7 hours of reperfusion. Clamping the right main pulmonary artery caused a significant increase in PVR in both groups. Differences in PVR over 7 hours were statistically significant between both groups (P= .01). LPD, Low-potassium dextran; GSH, glutathione; PVR, pulmonary vascular resistance; Anova, analysis of variance. The Journal of Thoracic and Cardiovascular Surgery 2005 130, 864-869DOI: (10.1016/j.jtcvs.2005.05.021) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 SA/LA ratio of the BALF phospholipid composition 2 hours after reperfusion compared with control BALF collected from recipient native lungs. SA/LA, Small to large aggregate; LPD, low-potassium dextran; GSH, glutathione. The Journal of Thoracic and Cardiovascular Surgery 2005 130, 864-869DOI: (10.1016/j.jtcvs.2005.05.021) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Myeloperoxidase activity of lung tissue after termination of the experiment to control tissue collected from recipient native lungs. LPD, Low-potassium dextran; GSH, glutathione. The Journal of Thoracic and Cardiovascular Surgery 2005 130, 864-869DOI: (10.1016/j.jtcvs.2005.05.021) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions