Volume 15, Issue 4, Pages (December 2008)

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Volume 15, Issue 4, Pages 227-231 (December 2008) Mebudipine and dibudipine protect PC12 cells against oxygen–glucose deprivation and glutamate-induced cell death Nahid Rahbar-Roshandel, Lili Razavi, Bahareh Tavakoli-Far, Massoud Mahmoudian Pathophysiology Volume 15, Issue 4, Pages 227-231 (December 2008) DOI: 10.1016/j.pathophys.2008.09.002 Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 (A) The effects of mebudipine and dibudipine in comparison with nimodipine on concurrently time schedule in glutamate-induced PC12 cells toxicity. The dashed bar shows the drug group and the white bar shows the control group. The inset demonstrates the difference between the effects of each drug on the test and the control group. (B). The effects of mebudipine and dibudipine in comparison with nimodipine on pre-3h time schedule in glutamate-induced PC12 cells toxicity. The dashed bar shows the drug group and the white bar shows the control group. The inset demonstrates the difference between the effects of each drug on the test and the control groups. (C) The effects of mebudipine and dibudipine in comparison with nimodipine on pre-24h time schedule in glutamate-induced PC12 cells toxicity. The dashed bar shows the drug group and the white bar shows the control group. The inset demonstrates the difference between the effects of each drug on the test and the control groups. *P<0.05, ***P<0.0005. Pathophysiology 2008 15, 227-231DOI: (10.1016/j.pathophys.2008.09.002) Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 (A) The effects of mebudipine and dibudipine in comparison with nimodipine on concurrently time schedule in OGD-induced PC12 cells injury. The dashed bar shows the drug group and the white bar shows the control group. The inset demonstrates the difference between the effects of each drug on the test and the control groups. (2) The effects of mebudipine and dibudipine in comparison with nimodipine on pre-3h time schedule in OGD-induced PC12 cells injury. The dashed bar shows the drug group and the white bar shows the control group. The inset demonstrates the difference between the effects of each drug on the test and the control groups. (C) The effects of mebudipine and dibudipine in comparison with nimodipine on pre-24h time schedule in OGD-induced PC12 cells injury. The dashed bar shows the drug group and the white bar shows the control group. The inset demonstrates the difference between the effects of each drug on the test and the control groups. *P<0.05, **P<0.005, ***P<0.0005. Pathophysiology 2008 15, 227-231DOI: (10.1016/j.pathophys.2008.09.002) Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 The effects of NMDA glutamate receptor antagonist (MK-801) on OGD-induced cell injury. ***P<0.0005. Pathophysiology 2008 15, 227-231DOI: (10.1016/j.pathophys.2008.09.002) Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions