Fogarty and percutaneous transluminal coronary angioplasty balloon injury induce comparable damage to the arterial wall but lead to different healing.

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Presentation transcript:

Fogarty and percutaneous transluminal coronary angioplasty balloon injury induce comparable damage to the arterial wall but lead to different healing responses Frits N.G. Doornekamp, MSc, Cornelius Borst, MD, PhD, Christian C. Haudenschild, MD, Mark J. Post, MD, PhD Journal of Vascular Surgery Volume 24, Issue 5, Pages 843-850 (November 1996) DOI: 10.1016/S0741-5214(96)70021-6 Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Anti-CD31 stained histologic sections 21 days after 2.5 cm Fogarty balloon (A) and 2 cm PTCA balloon (B) injury. Antibody binding is visualized with indirect alkaline phosphatase method. Red staining represents endothelial cells. Internal elastic lamina is marked with arrows. A shows polygonal morphologic characteristics of regenerated endothelial cells (arrowheads) in center of lesion covering large amount of intimal hyperplasia (i), whereas in center of PTCA induced lesions smaller amount of intimal hyperplasia (i) is covered by regenerated, phenotypically quiescent endothelial cells (B, arrowheads). Bar = 25 μm. Journal of Vascular Surgery 1996 24, 843-850DOI: (10.1016/S0741-5214(96)70021-6) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Anti-CD31 stained histologic sections 21 days after 2.5 cm Fogarty balloon (A) and 2 cm PTCA balloon (B) injury. Antibody binding is visualized with indirect alkaline phosphatase method. Red staining represents endothelial cells. Internal elastic lamina is marked with arrows. A shows polygonal morphologic characteristics of regenerated endothelial cells (arrowheads) in center of lesion covering large amount of intimal hyperplasia (i), whereas in center of PTCA induced lesions smaller amount of intimal hyperplasia (i) is covered by regenerated, phenotypically quiescent endothelial cells (B, arrowheads). Bar = 25 μm. Journal of Vascular Surgery 1996 24, 843-850DOI: (10.1016/S0741-5214(96)70021-6) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 MIB-1 staining of rabbit carotid arteries 3 days after Fogarty balloon (A) or PTCA balloon (B) injury. Antibody binding was visualized with indirect peroxidase method. Nuclei of proliferating cells were stained brown (arrowheads). Resting cells were stained blue. Notice conspicuous presence of proliferating cells in adventitia (a) after Fogarty (A) and PTCA balloon (B) injury. Bar = 25 μm. Journal of Vascular Surgery 1996 24, 843-850DOI: (10.1016/S0741-5214(96)70021-6) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 MIB-1 staining of rabbit carotid arteries 3 days after Fogarty balloon (A) or PTCA balloon (B) injury. Antibody binding was visualized with indirect peroxidase method. Nuclei of proliferating cells were stained brown (arrowheads). Resting cells were stained blue. Notice conspicuous presence of proliferating cells in adventitia (a) after Fogarty (A) and PTCA balloon (B) injury. Bar = 25 μm. Journal of Vascular Surgery 1996 24, 843-850DOI: (10.1016/S0741-5214(96)70021-6) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions