IgE in the diagnosis and treatment of allergic disease

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Presentation transcript:

IgE in the diagnosis and treatment of allergic disease Thomas A.E. Platts-Mills, MD, PhD, Alexander J. Schuyler, BS, BA, Elizabeth A. Erwin, MD, Scott P. Commins, MD, PhD, Judith A. Woodfolk, MBChB, PhD Journal of Allergy and Clinical Immunology Volume 137, Issue 6, Pages 1662-1670 (June 2016) DOI: 10.1016/j.jaci.2016.04.010 Copyright © 2016 Terms and Conditions

Fig 1 Allergens become airborne and are inhaled in the form of particles, which range from 5 to 30 μm in diameter (Table I). The number of allergen molecules free in the air is essentially zero, and none of the source materials are inhaled. Journal of Allergy and Clinical Immunology 2016 137, 1662-1670DOI: (10.1016/j.jaci.2016.04.010) Copyright © 2016 Terms and Conditions

Fig 2 Contrast between natural exposure to airborne allergen (A) and bronchial provocation with nebulized extract (B). Natural exposure is to relatively large particles, which contain a wide range of allergens and adjuvants. Journal of Allergy and Clinical Immunology 2016 137, 1662-1670DOI: (10.1016/j.jaci.2016.04.010) Copyright © 2016 Terms and Conditions

Fig 3 IgE antibodies in patients with EoE compared with those with 2 anaphylaxis syndromes: peanut and alpha-gal. Although IgE to milk, wheat, egg, and soy are common in children with EoE, the titers are generally low or very low. Journal of Allergy and Clinical Immunology 2016 137, 1662-1670DOI: (10.1016/j.jaci.2016.04.010) Copyright © 2016 Terms and Conditions

Fig 4 Contrast between 3 body surfaces that are relevant to the induction and maintenance of immune responses for food allergens: skin (keratinized squamous epithelium), esophagus (nonkeratinized squamous epithelium), and columnar epithelium in the intestines. We recognize that the lymphoid tissues draining the upper airways and mouth are also important for response to food allergens. Journal of Allergy and Clinical Immunology 2016 137, 1662-1670DOI: (10.1016/j.jaci.2016.04.010) Copyright © 2016 Terms and Conditions