Volume 1, Issue 5, Pages (October 2014)

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Volume 1, Issue 5, Pages 368-376 (October 2014) Psychological and pharmacological interventions for social anxiety disorder in adults: a systematic review and network meta-analysis Dr Evan Mayo-Wilson, DPhil, Sofia Dias, PhD, Ifigeneia Mavranezouli, PhD, Kayleigh Kew, MA, Prof David M Clark, DPhil, Prof A E Ades, PhD, Prof Stephen Pilling, PhD The Lancet Psychiatry Volume 1, Issue 5, Pages 368-376 (October 2014) DOI: 10.1016/S2215-0366(14)70329-3 Copyright © 2014 Mayo-Wilson et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 1 PRISMA flowchart PRISMA=Preferred Reporting Items for Systematic reviews and Meta-Analyses. The Lancet Psychiatry 2014 1, 368-376DOI: (10.1016/S2215-0366(14)70329-3) Copyright © 2014 Mayo-Wilson et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 2 Network diagram representing direct comparisons among classes The width of lines represents the number of trials in which each direct comparison is made. The size of each circle represents the number of people who received each treatment. CBT=cognitive–behavioural therapy. SNRI=serotonin–norepinephrine reuptake inhibitor. SSRI=selective serotonin-reuptake inhibitor. The Lancet Psychiatry 2014 1, 368-376DOI: (10.1016/S2215-0366(14)70329-3) Copyright © 2014 Mayo-Wilson et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 3 Effect of each class of intervention compared with waitlist Data are standardised mean difference and 95% credible intervals compared with waitlist as a reference. CBT=cognitive–behavioural therapy. SNRI=serotonin–norepinephrine reuptake inhibitor. SSRI=selective serotonin-reuptake inhibitor. The Lancet Psychiatry 2014 1, 368-376DOI: (10.1016/S2215-0366(14)70329-3) Copyright © 2014 Mayo-Wilson et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 4 Efficacy of classes of interventions Classes of interventions are ordered according to efficacy ranking from largest mean effect (top, left) to smallest mean effect (bottom, right). Data in blue represent the effects on symptoms of social anxiety (SMD [95% CrI]); SMD less than 0 favours the intervention in the row. Data in green represent the effects on recovery (RR [95% CrI]); RR greater than 1 favours the intervention in the column. Significant results are shaded dark blue and dark green. CBT=cognitive–behavioural therapy. CrI=credible interval. EXER=promotion of exercise. EXPO=exposure and social skills. MAOI=monoamine oxidase inhibitors. NSSA=noradrenergic and specific serotonergic antidepressants. OTHER=other psychological therapy. PDPT=psychodynamic psychotherapy. PSYP=psychological placebo. RR=risk ratio. SHNS=self-help without support. SHWS=self-help with support. SMD=standardised mean difference. SNRI=serotonin–norepinephrine reuptake inhibitors. SSRI=selective serotonin-reuptake inhibitor. The Lancet Psychiatry 2014 1, 368-376DOI: (10.1016/S2215-0366(14)70329-3) Copyright © 2014 Mayo-Wilson et al. Open Access article distributed under the terms of CC BY Terms and Conditions