Despo Ierodiakonou, MD, Dirkje S. Postma, MD, PhD, Gerard H

Slides:



Advertisements
Similar presentations
Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.
Advertisements

Severe adult-onset asthma: A distinct phenotype
Clarification concerning amoxicillin skin testing
Alexandra Kazaks, MA, RD, Janet Y. Uriu-Adams, PhD, Judith S
Päivi M. Salo, PhD, Samuel J
Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD 
Fatty acids, inflammation, and asthma
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
Ann-Marie M. Schoos, MD, PhD, Jacob D
Is 9 more than 2 also in allergic airway inflammation?
Desensitization to Chemotherapeutic Agents
Genome-wide interaction study of gene-by-occupational exposure and effects on FEV1 levels  Kim de Jong, PhD, Judith M. Vonk, PhD, Wim Timens, PhD, Yohan.
Fatty acids, inflammation, and asthma
Asthma therapy and airway remodeling
Rising prevalence of asthma is sex-specific in a US farming population
Genome-wide association study on the FEV1/FVC ratio in never-smokers identifies HHIP and FAM13A  Diana A. van der Plaat, MSc, Kim de Jong, PhD, Lies Lahousse,
Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J
Excessive gestational weight gain in first trimester is a risk factor for exacerbation of asthma during pregnancy: A prospective study of 1283 pregnancies 
The National Biome Initiative: An allergy perspective
High-resolution computed tomography scan and airway remodeling in children with severe asthma  Jacques de Blic, MD, Isabelle Tillie-Leblond, MD, PhD,
Peter M. Wolfgram, MD, David B. Allen, MD 
The future of allergy/immunology: Promising young investigators
Asthma treatment and asthma prevention: A tale of 2 parallel pathways
Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways 
Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA 
Reply Journal of Allergy and Clinical Immunology
Jon Genuneit, MD, MSc  Journal of Allergy and Clinical Immunology 
A survivor: The eosinophil as a regulator in asthma
High eosinophil count: A potential biomarker for assessing successful omalizumab treatment effects  William Busse, MD, Sheldon Spector, MD, Karin Rosén,
Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation  Leif Bjermer, MD  Journal of Allergy.
Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management  Scott H. Sicherer, MD, Hugh A. Sampson, MD  Journal.
Biosimilars and drug development in allergic and immunologic diseases
Daphne Koinis-Mitchell, PhD, Timothy Craig, DO, Cynthia A
News Beyond Our Pages Journal of Allergy and Clinical Immunology
Claus Bachert, MD, PhD, Cezmi A. Akdis, MD 
Update on the role of prostaglandins in allergic lung inflammation: Separating friends from foes, harder than you might think  Martin L. Moore, PhD, R.
Airway inflammation in occupational asthma caused by styrene
What is an “eosinophilic phenotype” of asthma?
Cephalosporin Side Chain Cross-reactivity
Medication use in children with asthma in Finland from 1995 to 2006
H. William Kelly, PharmD  Journal of Allergy and Clinical Immunology 
Autophagy: Nobel Prize 2016 and allergy and asthma research
Aaron M. Drucker, MD, Paula J. Harvey, PhD 
Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment
Advances in the approach to the patient with food allergy
Diagnosis and management of early asthma in preschool-aged children
Päivi M. Salo, PhD, Samuel J
Perinatal risk factors for bronchial hyperresponsiveness and atopy after a follow-up of 20 years  Judith M Vonk, MSc, H.Marike Boezen, PhD, Dirkje S Postma,
A single intervention for cockroach control reduces cockroach exposure and asthma morbidity in children  Felicia A. Rabito, PhD, MPH, John C. Carlson,
Alexandra Kazaks, MA, RD, Janet Y. Uriu-Adams, PhD, Judith S
Corinne A. Keet, MD, MS, Wayne G. Shreffler, MD, PhD, Roger D
Prevention of food allergy: Beyond peanut
Day-care attendance, position in sibship, and early childhood wheezing: A population- based birth cohort study  Nicolaos C. Nicolaou, MD, MPhil, Angela.
Frederika A. van Nimwegen, MSc, John Penders, PhD, Ellen E
Lars Pedersen, MD, PhD, Thomas K
Measles and immunomodulation
Prescott G. Woodruff, MD, MPH, Ramin Khashayar, MD, Stephen C
Macrolide antibiotics and asthma treatment
Frederikke K. Lomholt, BMSc, Sune F. Nielsen, PhD, Børge G
Asthma: The past, future, environment, and costs
Environmental factors and eosinophilic esophagitis
News Beyond Our Pages Journal of Allergy and Clinical Immunology
Dietary therapy for eosinophilic esophagitis
Advances in pediatric asthma in 2007
News Beyond Our Pages Journal of Allergy and Clinical Immunology
Negative affect, medication adherence, and asthma control in children
Safety and efficacy of repeated monthly carboplatin desensitization
Interleukin-1 receptor–like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood  Olga E.M. Savenije, MD, Marjan Kerkhof,
Natural history of cow’s milk allergy
Primary prevention of asthma and allergy
Presentation transcript:

TGF-β1 polymorphisms and asthma severity, airway inflammation, and remodeling  Despo Ierodiakonou, MD, Dirkje S. Postma, MD, PhD, Gerard H. Koppelman, MD, PhD, Jorrit Gerritsen, MD, PhD, Nick H.T. ten Hacken, MD, PhD, Wim Timens, MD, PhD, H. Marike Boezen, PhD, Judith M. Vonk, PhD  Journal of Allergy and Clinical Immunology  Volume 131, Issue 2, Pages 582-585 (February 2013) DOI: 10.1016/j.jaci.2012.08.013 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Associations between subepithelial eosinophil counts and smoking status (A), rs6957 (B), rs6957 in never-smokers (C) and in ever-smokers (D). Associations between basement membrane thickness and smoking status (E), rs6957 (F), rs6957 in never-smokers (G) and in ever-smokers (H). Mean (95% CI) eosinophil counts are given by generalized linear models adjusted for sex, age, and inhaled corticosteroid use. Journal of Allergy and Clinical Immunology 2013 131, 582-585DOI: (10.1016/j.jaci.2012.08.013) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Journal of Allergy and Clinical Immunology 2013 131, 582-585DOI: (10.1016/j.jaci.2012.08.013) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Journal of Allergy and Clinical Immunology 2013 131, 582-585DOI: (10.1016/j.jaci.2012.08.013) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Journal of Allergy and Clinical Immunology 2013 131, 582-585DOI: (10.1016/j.jaci.2012.08.013) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions