Figure 5 The nephron-centric model of renal transplant fibrosis based on the injury-related molecular events observed in biopsy samples in the first year.

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Figure 5 The nephron-centric model of renal transplant fibrosis based on the injury-related molecular events observed in biopsy samples in the first year post-transplantation Figure 5 | The nephron-centric model of renal transplant fibrosis based on the injury-related molecular events observed in biopsy samples in the first year post-transplantation. The model proposes that injured nephrons mount a highly time-dependent programme in response to wounding in which they either restore full function or shut down and undergo tubular atrophy and interstitial fibrosis with remodelling of the adjacent tissue. AKI, acute kidney injury; GFR, glomerular filtration rate; TA/IF, tubular atrophy and interstitial fibrosis. Modified with permission from the American Society for Clinical Investigation © Venner, J.M. et al. JCI Insight 1, e85323 (2016). Modified with permission from the American Society for Clinical Investigation © Venner, J.M. et al. JCI Insight 1, e85323 (2016). Halloran, P. F. et al. (2016) Molecular assessment of disease states in kidney transplant biopsy samples Nat. Rev. Nephrol. doi:10.1038/nrneph.2016.85