Incidence of iatrogenic opioid dependence or abuse in patients with pain who were exposed to opioid analgesic therapy: a systematic review and meta-analysis

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Presentation transcript:

Incidence of iatrogenic opioid dependence or abuse in patients with pain who were exposed to opioid analgesic therapy: a systematic review and meta-analysis C. Higgins, B.H. Smith, K. Matthews British Journal of Anaesthesia Volume 120, Issue 6, Pages 1335-1344 (June 2018) DOI: 10.1016/j.bja.2018.03.009 Copyright © 2018 British Journal of Anaesthesia Terms and Conditions

Fig 1 Eligibility screening procedures and the total number of articles included in the review, shown on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) four-phase flow diagram. British Journal of Anaesthesia 2018 120, 1335-1344DOI: (10.1016/j.bja.2018.03.009) Copyright © 2018 British Journal of Anaesthesia Terms and Conditions

Fig 2 Meta-analysis (random effects model) of overall study findings of the incidence of iatrogenic opioid dependence or abuse. Studies are reported by ascending year of publication. Note: It is recognised that incidence cannot decrease below zero; however, the company providing the CMA software (Biostat Inc., Englewood, NJ, USA) confirmed that it is not possible to generate a scale that is not symmetrical around zero. CI, confidence interval. British Journal of Anaesthesia 2018 120, 1335-1344DOI: (10.1016/j.bja.2018.03.009) Copyright © 2018 British Journal of Anaesthesia Terms and Conditions

Fig 3 Sensitivity analysis of the incidence of iatrogenic opioid dependence or abuse by DSM-IV and ICD-9 diagnostic criteria for identifying dependence or abuse. CI, confidence interval. British Journal of Anaesthesia 2018 120, 1335-1344DOI: (10.1016/j.bja.2018.03.009) Copyright © 2018 British Journal of Anaesthesia Terms and Conditions

Fig 4 Sensitivity analysis of the incidence of iatrogenic opioid dependence or abuse by strength of prescription opioid analgesics. CI, confidence interval. British Journal of Anaesthesia 2018 120, 1335-1344DOI: (10.1016/j.bja.2018.03.009) Copyright © 2018 British Journal of Anaesthesia Terms and Conditions

Fig 5 Sensitivity analysis of the incidence of iatrogenic opioid dependence or abuse by length of exposure to opioid analgesics. CI, confidence interval. British Journal of Anaesthesia 2018 120, 1335-1344DOI: (10.1016/j.bja.2018.03.009) Copyright © 2018 British Journal of Anaesthesia Terms and Conditions