A Quantitative-Trait Analysis of Human Plasma–Dopamine β-Hydroxylase Activity: Evidence for a Major Functional Polymorphism at the DBH Locus Cyrus P.

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A Quantitative-Trait Analysis of Human Plasma–Dopamine β-Hydroxylase Activity: Evidence for a Major Functional Polymorphism at the DBH Locus Cyrus P. Zabetian, George M. Anderson, Sarah G. Buxbaum, Robert C. Elston, Hiroshi Ichinose, Toshiharu Nagatsu, Kwang-Soo Kim, Chun-Hyung Kim, Robert T. Malison, Joel Gelernter, Joseph F. Cubells The American Journal of Human Genetics Volume 68, Issue 2, Pages 515-522 (February 2001) DOI: 10.1086/318198 Copyright © 2001 The American Society of Human Genetics Terms and Conditions

Figure 1 Distribution of plasma-DβH activity in AA (A), EA (B), and Jp (C). Subjects are grouped in successive 2.5-nmol/min/ml increments. The hatched bar indicates the results for the very low DβH-activity group. The EA and Jp mean activity values differed significantly (P<.01, one-way ANOVA; followed by Dunnett C post-hoc test). The American Journal of Human Genetics 2001 68, 515-522DOI: (10.1086/318198) Copyright © 2001 The American Society of Human Genetics Terms and Conditions

Figure 2 Distribution of square-root plasma-DβH activity, by genotype, at DBH polymorphism −1021C→T in AA (A), EA (B), and Jp (C). Green bars denote T/T homozygotes, red bars denote C/T heterozygotes, and blue bars denote C/C homozygotes. A single C/C homozygote with an extreme activity value of 11.2 square-root nmol/min/ml was omitted from the EA distribution plot, for the purpose of graphical clarity. The American Journal of Human Genetics 2001 68, 515-522DOI: (10.1086/318198) Copyright © 2001 The American Society of Human Genetics Terms and Conditions