The Importance of Timing

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The Importance of Timing Richard S. Mann, Clare E. Howard Cell Volume 164, Issue 3, Pages 347-348 (January 2016) DOI: 10.1016/j.cell.2016.01.010 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Temporal Regulation of Proneural Protein Activity Proneural bHLH proteins are expressed at low levels in proneural clusters. Protein levels increase in one specified neural precursor, while being repressed in neighboring cells. Quan et al. show that, at the peak of expression, proneural proteins are phosphorylated, which prevents DNA binding. This inactivation of proneural bHLH factors is essential for the progression of neurogenesis. Cell 2016 164, 347-348DOI: (10.1016/j.cell.2016.01.010) Copyright © 2016 Elsevier Inc. Terms and Conditions