Gregory C. Gaines, MD, M. Burress Welborn III, MD, Lyle L

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Presentation transcript:

Attenuation of skeletal muscle ischemia/reperfusion injury by inhibition of tumor necrosis factor Gregory C. Gaines, MD, M.Burress Welborn III, MD, Lyle L. Moldawer, PhD, Thomas S. Huber, MD, PhD, Timothy R.S. Harward, MD, James M. Seeger, MD Journal of Vascular Surgery Volume 29, Issue 2, Pages 370-376 (February 1999) DOI: 10.1016/S0741-5214(99)70390-3 Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig 1 Skeletal muscle injury index (SMII) as measured by means of the uptake of Tc99 pyrophosphate in the soleus muscle. Animals were subjected to bilateral hindlimb ischemia (IR), bilateral hindlimb ischemia and pretreatment with STNFRI (PRE), bilateral hindlimb ischemia and STNFRI treatment at time of reperfusion (POST), or sham operation (SHAM). The values were compared with one-way analysis of variance, and the significant differences were identified with either the Student-Newman-Keuls or Dunn test. A P value less than .05 was accepted as significant and is marked with an *. Journal of Vascular Surgery 1999 29, 370-376DOI: (10.1016/S0741-5214(99)70390-3) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig 2 Skeletal muscle capillary membrane permeability index (MPI), as measured by means of the uptake of I125 albumin in the soleus muscle. Animals were subjected to bilateral hindlimb ischemia (IR), bilateral hindlimb ischemia and pretreatment with STNFRI (PRE), bilateral hindlimb ischemia and STNFRI treatment at time of reperfusion (POST), or sham operation (SHAM). The values were compared with one-way analysis of variance, and the significant differences were identified with either the Student-Newman-Keuls or Dunn test. A P value less than .05 was accepted as significant and is marked with an *. Journal of Vascular Surgery 1999 29, 370-376DOI: (10.1016/S0741-5214(99)70390-3) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig 3 Pulmonary neutrophil sequestration, as measured by means of lung myeloperoxidase content (MPO). Animals were subjected to bilateral hindlimb ischemia (IR), bilateral hindlimb ischemia and pretreatment with STNFRI (PRE), or sham operation (SHAM). The values were compared with one-way analysis of variance, and the significant differences were identified with a Student-Newman-Keuls test. A P value less than .05 was accepted as significant and is marked with an *. Journal of Vascular Surgery 1999 29, 370-376DOI: (10.1016/S0741-5214(99)70390-3) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig 4 Hepatocellular injury, as measured by means of serum aspartate aminotransferase (AST) concentrations versus time. A time of –4 represents AST concentrations at baseline (insertion of atrialcaval catheter) before the onset of ischemia. A time of 0 represents the onset of reperfusion. Animals were subjected to bilateral hindlimb ischemia (IR), bilateral hindlimb ischemia and pretreatment with STNFRI (PRE), or sham operation (SHAM). The values were compared with one-way analysis of variance, and the significant differences were identified with the Student-Newman-Keuls test. A P value less than .05 was accepted as significant. A significant difference between the IR and SHAM group is marked with an *, whereas a significant difference between the PRE and SHAM groups is marked with a #. Journal of Vascular Surgery 1999 29, 370-376DOI: (10.1016/S0741-5214(99)70390-3) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig 5 The maximal tumor necrosis factor (TNF) levels during the ischemic period for the treatment groups. Animals were subjected to bilateral hindlimb ischemia (IR) or sham operation (SHAM). The values were compared with a rank sum test. A P value less than .05 was accepted as significant and is marked with an *. Journal of Vascular Surgery 1999 29, 370-376DOI: (10.1016/S0741-5214(99)70390-3) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions