Elevated messenger RNA expression and plasma protein levels of osteopontin and matrix metalloproteinase types 2 and 9 in patients with ascending aortic.

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Presentation transcript:

Elevated messenger RNA expression and plasma protein levels of osteopontin and matrix metalloproteinase types 2 and 9 in patients with ascending aortic aneurysms Tuija Huusko, MSc, Tuire Salonurmi, PhD, Panu Taskinen, MD, PhD, Johanna Liinamaa, MD, PhD, Tatu Juvonen, MD, PhD, Paavo Pääkkö, MD, PhD, Markku Savolainen, MD, PhD, Sakari Kakko, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 145, Issue 4, Pages 1117-1123 (April 2013) DOI: 10.1016/j.jtcvs.2012.04.008 Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Analysis of plasma protein levels of OPN, MMP-2, MMP-9, and TIMP-1. ∗∗∗Statistical significances between aneurysm groups and controls are shown P < .001 (Mann-Whitney U test). AscAA, Ascending aortic aneurysm; AAA, abdominal aortic aneurysm; OPN, osteopontin; MMP-2, matrix metalloproteinase type 2; MMP-9, matrix metalloproteinase type 9; TIMP-1, tissue inhibitor of matrix metalloproteinases type 1. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 1117-1123DOI: (10.1016/j.jtcvs.2012.04.008) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Immunostaining study results of OPN and MMP-2 (original magnification ×20). Immunohistochemistry of OPN in AscAA tissue (A) and control tissue (B). Immunoreactivity of MMP-2 in AscAA tissue (C) and in control tissue (D). Histologic features of aortic wall are stained with hematoxylin and eosin. OPN, Osteopontin; MMP-2, matrix metalloproteinase type 2; AscAA, ascending aortic aneurysm. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 1117-1123DOI: (10.1016/j.jtcvs.2012.04.008) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions