Intra-articular treatment of hip osteoarthritis: a randomized trial of hyaluronic acid, corticosteroid, and isotonic saline E. Qvistgaard, M.D., R. Christensen,

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Intra-articular treatment of hip osteoarthritis: a randomized trial of hyaluronic acid, corticosteroid, and isotonic saline E. Qvistgaard, M.D., R. Christensen, M.Sc., S. Torp-Pedersen, M.D., H. Bliddal, Ph.D., M.D. Osteoarthritis and Cartilage Volume 14, Issue 2, Pages 163-170 (February 2006) DOI: 10.1016/j.joca.2005.09.007 Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 1 Flow diagram of the study population according to the CONSORT statement. Drop-outs were for HA: at 14 days, 1 patient (pt); 28 days, 1 pt.; 90 days, 2 pt. Drop-outs for saline were: 28 days, 1 pt.; 90 days, 2 pt.; and for corticosteroid: 28 days, 2 pt.; 90 days, 4 pt. Osteoarthritis and Cartilage 2006 14, 163-170DOI: (10.1016/j.joca.2005.09.007) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 2 The injection procedure. Note the antero-lateral approach, which was used in all cases in the present study after triple skin disinfection and by applying non-touch technique. Osteoarthritis and Cartilage 2006 14, 163-170DOI: (10.1016/j.joca.2005.09.007) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 3 Values are mean±SE following 3 months of intervention in 101 patients with hip OA treated with injections of hyaluronic acid (HA, n=33), corticosteroid (n=32), or placebo (saline, n=36). (a) For the primary outcome ‘Pain on walking’. (b) For the outcome ‘Pain at rest’. Osteoarthritis and Cartilage 2006 14, 163-170DOI: (10.1016/j.joca.2005.09.007) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 4 Values of (a) The Lequesne index and (b) The WOMAC scores given as mean±SE. Osteoarthritis and Cartilage 2006 14, 163-170DOI: (10.1016/j.joca.2005.09.007) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 5 Patient's global assessments given as mean±SE. Osteoarthritis and Cartilage 2006 14, 163-170DOI: (10.1016/j.joca.2005.09.007) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 6 Values are mean±SE for the change (Δ) in ‘Pain on walking’. (a) Dichotomized according to Kellgren grade ([I–II]/[III–IV]). (b) Dichotomized according to effusion in joint ([no]/[yes]). Osteoarthritis and Cartilage 2006 14, 163-170DOI: (10.1016/j.joca.2005.09.007) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions