When Cancer Cells Are Given Lemo[NH3]s, They Make Lemo[NH3]ade

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When Cancer Cells Are Given Lemo[NH3]s, They Make Lemo[NH3]ade Mengrou Shan, Costas A. Lyssiotis Cell Metabolism Volume 26, Issue 6, Pages 811-813 (December 2017) DOI: 10.1016/j.cmet.2017.11.008 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Ammonia Capture in ER+ Breast Cancer In the first step of glutaminolysis, glutaminases (GLS) catalyze the conversion of glutamine (Gln) to glutamate (Glu) by releasing the amide group as ammonia/ammonium (NH3/NH4+). Glu can further be converted to alpha-ketoglutarate (αKG) by loss of the amino group, either via glutamate dehydrogenase (GDH) through the oxidative deamination of Glu, or via transaminase-mediated transfer. Reciprocally, NH4+ can be assimilated through the reductive amination of αKG catalyzed by GDH or through the amidation of Glu via glutamate synthetase (GS). Asp, aspartate; BCAAs, branched-chain amino acids; Pro, proline. Cell Metabolism 2017 26, 811-813DOI: (10.1016/j.cmet.2017.11.008) Copyright © 2017 Elsevier Inc. Terms and Conditions