Forkhead box protein 3 (FOXP3) mutations lead to increased TH17 cell numbers and regulatory T-cell instability Laura Passerini, PhD, Sven Olek, PhD,

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Forkhead box protein 3 (FOXP3) mutations lead to increased TH17 cell numbers and regulatory T-cell instability Laura Passerini, PhD, Sven Olek, PhD, Sara Di Nunzio, PhD, Federica Barzaghi, MD, Sophie Hambleton, MD, Mario Abinun, MD, Alberto Tommasini, MD, Silvia Vignola, MD, Marco Cipolli, MD, Mario Amendola, PhD, Luigi Naldini, MD, Luisa Guidi, MD, Massimiliano Cecconi, BSc, Maria G. Roncarolo, MD, Rosa Bacchetta, MD Journal of Allergy and Clinical Immunology Volume 128, Issue 6, Pages 1376-1379.e1 (December 2011) DOI: 10.1016/j.jaci.2011.09.010 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A and B, IL-17A/IFN-γ production by CD4+ T cells. TPA, Tetradenoyl phorbol acetate. C, Retinoic acid–related orphan receptor variant 2 (RORC2) mRNA expression. D, Treg cell–specific demethylated region (TSDR) demethylation in whole blood. E, FOXP3 in CD4+CCR6+CD161+/CD161− T cells. F, IL-6 and IL-23 levels in sera. G, IL-17A production by HDs’ and patients’ Treg cell clones/lines. H, IL-17A levels on FOXP3 knockdown. In Fig 1, B-F, circles, subjects older than 12 years; triangles, subjects younger than 2 years. The Mann-Whitney U test was used in all but Fig 1, E/H (Wilcoxon signed-rank test). Middle lines indicate medians. NS, Not significant Journal of Allergy and Clinical Immunology 2011 128, 1376-1379.e1DOI: (10.1016/j.jaci.2011.09.010) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions