Why men are at higher risk for hepatocellular carcinoma?

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Presentation transcript:

Why men are at higher risk for hepatocellular carcinoma? Vincent W. Keng, David A. Largaespada, Augusto Villanueva Journal of Hepatology Volume 57, Issue 2, Pages 453-454 (August 2012) DOI: 10.1016/j.jhep.2012.03.004 Copyright © 2012 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Summary of the role of sex hormones in HCC. Different data indicate a pro-tumorigenic role of androgens in both the cirrhotic and normal liver. However, evidence from experimental models of chemically-induced HCC suggests that estrogens may be protective in this setting by interfering with IL6 production and FOXA DNA binding sites. Journal of Hepatology 2012 57, 453-454DOI: (10.1016/j.jhep.2012.03.004) Copyright © 2012 European Association for the Study of the Liver Terms and Conditions