Volume 52, Issue 3, Pages (March 2015)

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Volume 52, Issue 3, Pages 314-319 (March 2015) Is Magnetic Resonance Spectroscopy Capable of Detecting Metabolic Abnormalities in Neurofibromatosis Type 1 That Are Not Revealed in Brain Parenchyma of Normal Appearance? Antonio Carlos Pondé Rodrigues, MD, José Roberto Lopes Ferraz-Filho, MD, PhD, Ulysses S. Torres, MD, Antônio José da Rocha, MD, PhD, Marcos Pontes Muniz, MD, PhD, Antônio Soares Souza, MD, PhD, Eny Maria Goloni-Bertollo, PhD, Érika Cristina Pavarino, PhD Pediatric Neurology Volume 52, Issue 3, Pages 314-319 (March 2015) DOI: 10.1016/j.pediatrneurol.2014.11.014 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure Fluid attenuation inversion recovery images of neurofibromatosis type 1 (NF1) children with (A) and without (B) T2-weighted hyperintensities and of a control (C). Single voxel magnetic resonance spectroscopy of the left capsulolenticular region in NF1 patients (A, B) shows increased choline/creatine and myoinositol/creatine ratios as compared with the control (C); such metabolic abnormalities found both in normal-appearing and in non-normal-appearing brain parenchyma allowed differentiating NF1 patients from controls. The NF1 patient in part A (with T2-weighted hyperintensities) demonstrates slightly higher myoinositol/creatine ratio than the individual in part B (without T2-weighted hyperintensities), which allowed metabolic distinction between patients with and without T2-weighted hyperintensities. N-acetyl aspartate/creatine ratios in both NF1 patients are preserved (i.e., similar to the control), indicating functional neuronal stability in the region. (The color version of this figure is available in the online edition.) Pediatric Neurology 2015 52, 314-319DOI: (10.1016/j.pediatrneurol.2014.11.014) Copyright © 2015 Elsevier Inc. Terms and Conditions