Curvularia—favorable response to oral itraconazole therapy in two patients with locally invasive phaeohyphomycosis  A. Safdar  Clinical Microbiology and Infection  Volume 9, Issue 12, Pages 1219-1223 (December 2003) DOI: 10.1111/j.1469-0691.2003.00791.x Copyright © 2003 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 1 Invasive tinea unguium involving the distal great toe in patient 1 prior to initiation of oral itraconazole therapy. A granulomatous frail, pink verrucous excrescence can be seen at the distal nail bed (inset). Clinical Microbiology and Infection 2003 9, 1219-1223DOI: (10.1111/j.1469-0691.2003.00791.x) Copyright © 2003 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 2 Computed tomography scan of the paranasal sinus prior to antifungal therapy in patient 2. There is near-complete opacification of the left frontal sinus, and the right sinus mucosa shows signs of inflammation (top panel, arrows). In the middle panel, the left sphenoid sinus shows prominent signs of inflammation, compared to the right sinus (arrowhead). Similarly, the bottom panel shows bilateral maxillary sinus involvement with marked mucosal edema and thickening (arrows). Clinical Microbiology and Infection 2003 9, 1219-1223DOI: (10.1111/j.1469-0691.2003.00791.x) Copyright © 2003 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 3 Histologic examination of ethamoid sinus mucosa (Gomori's methenamine–silver (GMS) stain ×100; H&E ×400, inset). Prominent intramucosal septate, branching hyphal forms are seen that are indistinguishable from invasive hyalohyphomycosis in the GMS-stained sample. The arrowheads indicate dark-pigmented hyphae within the sinus mucosa on H&E stain, suggesting invasive phaeohyphomycosis (inset). Clinical Microbiology and Infection 2003 9, 1219-1223DOI: (10.1111/j.1469-0691.2003.00791.x) Copyright © 2003 European Society of Clinical Infectious Diseases Terms and Conditions