Hormone-induced delayed ovulation affects early embryonic development

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Presentation transcript:

Hormone-induced delayed ovulation affects early embryonic development Ann-Kathrin Bittner, M.D., Bernhard Horsthemke, Ph.D., Elke Winterhager, Ph.D., Ruth Grümmer, Ph.D. Fertility and Sterility Volume 95, Issue 7, Pages 2390-2394 (June 2011) DOI: 10.1016/j.fertnstert.2011.03.022 Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Ovaries of untreated (A) and cetrorelix-treated mice (B). Control ovaries show abundant corpora lutea (CL), whereas ovaries of cetrorelix-treated mice reveal high numbers of tertiary follicles (TFs). Scale bar = 200 μm. (C) Number of corpora lutea decreased dose dependently after cetrorelix-treatment (significant for 50 μg cetrorelix group). No ruptured follicles, as signs of ovulation, were observed in ovaries of mice treated with 50 μg cetrorelix (D), but the number of tertiary follicles increased significantly (E). After cetrorelix treatment, ovarian weight as percentage of body weight (BW) decreased slightly compared with controls (F). Controls, n = 9; cetrorelix-treated group, n = 4; ∗P<0.05 and ∗∗P<0.005 compared with controls. Fertility and Sterility 2011 95, 2390-2394DOI: (10.1016/j.fertnstert.2011.03.022) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Delayed ovulation induced by Cetrorelix reduced the number of regularly developed embryos per mouse at 17.5 dpc (A). Whereas no significant difference was observed in intrauterine deceased embryos (B), a significant increase in resorption sites was observed in the cetrorelix-treated group (C). (D) Resorption site (arrow) at dissection on 17.5 dpc in mice with cetrorelix-mediated delayed ovulation. Scale bar = 0.5 cm; Cetro = cetrorelix; controls, n = 6; cetrorelix treated group, n = 10; ∗P<0.05 compared with controls. Fertility and Sterility 2011 95, 2390-2394DOI: (10.1016/j.fertnstert.2011.03.022) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Weight of regularly developed embryos (A) and placentas (B) in cetrorelix-treated mice compared with controls at 17.5 dpc. A significant decrease in embryonic weight is observed (A), but placental weight was comparable to controls (B); this results in a significant increase in placental/embryonic weight ratio in the delayed ovulation group (C). Controls, n = 39; cetrorelix-treated group, n = 49; ∗P<0.005 compared with controls. Fertility and Sterility 2011 95, 2390-2394DOI: (10.1016/j.fertnstert.2011.03.022) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions