Cardiovascular Regeneration: Pushing and Pulling on Progenitors

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Cardiovascular Regeneration: Pushing and Pulling on Progenitors Matthew L. Steinhauser, Richard T. Lee  Cell Stem Cell  Volume 4, Issue 4, Pages 277-278 (April 2009) DOI: 10.1016/j.stem.2009.03.008 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 Synergism of G-CSF Therapy with Inhibition of Proteolytic Degradation of SDF-1 Results in Progenitor Recruitment to the Heart after Myocardial Infarction (Left) With G-CSF monotherapy, mobilized progenitors do not receive a homing signal to guide migration to the heart. (Right) Inhibition of proteolytic cleavage of SDF-1, in concert with G-CSF therapy, restores progenitor homing. Cell Stem Cell 2009 4, 277-278DOI: (10.1016/j.stem.2009.03.008) Copyright © 2009 Elsevier Inc. Terms and Conditions