A Comparison of the Kinetics of Nucleated Cells and CD34+ Cells in Neonatal Peripheral Blood and Cord Blood Joong-Pyo Kim, Young-Ho Lee, Young-Ah Lee,

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Presentation transcript:

A Comparison of the Kinetics of Nucleated Cells and CD34+ Cells in Neonatal Peripheral Blood and Cord Blood Joong-Pyo Kim, Young-Ho Lee, Young-Ah Lee, Young-Dae Kim Biology of Blood and Marrow Transplantation Volume 13, Issue 4, Pages 478-485 (April 2007) DOI: 10.1016/j.bbmt.2006.12.446 Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Kinetics of blood cell counts in cord blood and peripheral blood of newborns at 0 (NB-0), 24 (NB-24), and 48 (NB-48) hours after delivery. The WBC counts as well as neutrophil counts of CB were lower than those of the NB at delivery, and increased until 24 hours then decreased to 48 hours. The correlation coefficients between WBC counts and neutrophil counts were statistically significant (r = .89 at CB, .92 at NB-0, .95 at NB-24, and .95 at NB-48). Biology of Blood and Marrow Transplantation 2007 13, 478-485DOI: (10.1016/j.bbmt.2006.12.446) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Kinetics of lymphocytes in cord blood and peripheral blood of newborns at 0 (NB-0), 24 (NB-24), and 48 (NB-48) hours after delivery. There were no differences in CD3+ cell and CD19+ cell counts between CB and NB at 0, 24, and 48 hours postnatally; however, the CD16/56+ cell counts significantly decreased in the CB at 48 hours postnatally. Biology of Blood and Marrow Transplantation 2007 13, 478-485DOI: (10.1016/j.bbmt.2006.12.446) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Kinetics of CD34+ cell subsets in cord blood and peripheral blood of newborns at 0 (NB-0), 24 (NB-24), and 48 (NB-48) hours after delivery. The number of CD34+ cells as well as CD34+CXCR4+ cells, CD34+CD49d+ cells and CD34+CD44+ cells in CB were significantly higher than those in the NB at delivery, which decreased gradually until 48 hours after delivery. Biology of Blood and Marrow Transplantation 2007 13, 478-485DOI: (10.1016/j.bbmt.2006.12.446) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 Kinetics of CFU-GM counts in cord blood and peripheral blood of newborns at 0 (NB-0), 24 (NB-24), and 48 (NB-48) hours after delivery. The number of CFU-GM in CB was significantly higher than that of NB at delivery, which gradually decreased until 48 hours after delivery. Biology of Blood and Marrow Transplantation 2007 13, 478-485DOI: (10.1016/j.bbmt.2006.12.446) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 5 Kinetics of apoptotic cells and necrotic cells in cord blood and peripheral blood of newborns at 0 (NB-0), 24 (NB-24), and 48 (NB-48) hours after delivery. The difference in incidence of apoptosis was not statistically significant in the comparison between CB and the NB at 0, 24, and 48 hours postnatally. Biology of Blood and Marrow Transplantation 2007 13, 478-485DOI: (10.1016/j.bbmt.2006.12.446) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions