Management of refractory early-stage cutaneous T-cell lymphoma (mycosis fungoides) with a combination of oral bexarotene and psoralen plus ultraviolet.

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Presentation transcript:

Management of refractory early-stage cutaneous T-cell lymphoma (mycosis fungoides) with a combination of oral bexarotene and psoralen plus ultraviolet bath therapy Margit A Huber, MD, Karin Kunzi-Rapp, MD, PhD, Gyde Staib, MD, Karin Scharffetter-Kochanek, MD Journal of the American Academy of Dermatology Volume 50, Issue 3, Pages 475-476 (March 2004) DOI: 10.1016/S0190-9622(03)02488-5

Fig 1 Representative cutaneous lesions in flexural fossae of the lower extremities during combination therapy with oral bexarotene and PUVA bath therapy in a patient with mycosis fungoides. Six weeks after initiation of therapy there is marked improvement of lesions on the left leg, which received additional PUVA irradiation, whereas cutaneous T-cell lymphoma lesions on the right lower extremity (not treated with UV therapy) manifest as partly elevated erythematous plaques. Journal of the American Academy of Dermatology 2004 50, 475-476DOI: (10.1016/S0190-9622(03)02488-5)

Fig 2 Cutaneous T-cell lymphoma (CTCL) lesions in Fig 1 at week 16 from start of therapy. Progressive improvement is evident. Psoralen plus ultraviolet A therapy of the entire body surface has been performed for 4 weeks. Complete clearance of representative CTCL lesions on the left leg is evident, as is significant clearance on the right leg. Journal of the American Academy of Dermatology 2004 50, 475-476DOI: (10.1016/S0190-9622(03)02488-5)