Electrocardiographic changes during continuous intravenous application of bupivacaine in neonatal pigs J Mauch, A.P.N. Kutter, C Madjdpour, N Spielmann,

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Electrocardiographic changes during continuous intravenous application of bupivacaine in neonatal pigs J Mauch, A.P.N. Kutter, C Madjdpour, N Spielmann, C Balmer, A Frotzler, R Bettschart-Wolfensberger, M Weiss British Journal of Anaesthesia Volume 105, Issue 4, Pages 437-441 (October 2010) DOI: 10.1093/bja/aeq197 Copyright © 2010 The Author(s) Terms and Conditions

Fig 1 T-wave increase in percentage above baseline at different amounts of bupivacaine infused. n=15 in both groups. British Journal of Anaesthesia 2010 105, 437-441DOI: (10.1093/bja/aeq197) Copyright © 2010 The Author(s) Terms and Conditions

Fig 2 Typical ECG before (a), after 1.25 mg kg−1 (b), 2.5 mg kg−1 (c), and 5 mg kg−1 (d) bupivacaine infused (Pig no. 1–2). British Journal of Anaesthesia 2010 105, 437-441DOI: (10.1093/bja/aeq197) Copyright © 2010 The Author(s) Terms and Conditions

Fig 3 ECG with extreme T-elevation caused by bupivacaine. Trace before (a), after 1.25 mg kg−1 (b), 2.5 mg kg−1 (c), and 5 mg kg−1 (d) bupivacaine infused (Pig no. 2–9). British Journal of Anaesthesia 2010 105, 437-441DOI: (10.1093/bja/aeq197) Copyright © 2010 The Author(s) Terms and Conditions

Fig 4 Percentage of pigs with positive T-wave elevation (≥25% baseline) at different doses bupivacaine infused. n=15 in both groups. British Journal of Anaesthesia 2010 105, 437-441DOI: (10.1093/bja/aeq197) Copyright © 2010 The Author(s) Terms and Conditions

Fig 5 Changes in heart rate (%) after i.v. infusion of 1.25, 2.5, and 5 mg kg−1 bupivacaine. n=15 in both groups. British Journal of Anaesthesia 2010 105, 437-441DOI: (10.1093/bja/aeq197) Copyright © 2010 The Author(s) Terms and Conditions