Total Synthesis of Aplyviolene

Slides:

Advertisements

Similar presentations

Proposed Synthesis of Haliclonin A Stefan Breitenlechner, Angélique Fortier, James Mousseau, Marie-Noelle Roy, Frédéric Vallée aka: 7 th Heaven.

Advertisements

1 Charette/Collins Synthesis Day May Université de Montréal, Montréal, Qc Charette/Collins Synthesis Day May Université de Montréal, Montréal,

Total Synthesis of (+)-Saxitoxin

Amphidinolide A Isolation: 1. Kobayashi, J. et al. Tetrahedron Lett. 1986, 27, Kobayashi, J. et al. J. Nat. Prod. 1991, 54, Biological Activity:

Total Synthesis of (±)-Longifolene Yiyun Peng March 4th, 2013 W. Oppolzer, T. Godel, J. Am. Chem. Soc. 1978, 100, 2583 – 2584.

© Prentice Hall 2001Chapter 51 Hydrogen Halide Addition The addition of a hydrogen halide to an alkyne follows Markovnikov’s rule because a secondary vinylic.

1 Total Syntheses of Strychnine Song jin

Discussion Meeting Mechanisms Stereoselective Construction of the Tricyclic Core of Neoliacinic Acid Clark, J. S.; Baxter, C. A.; Dossetter, A. G.; Poigny,

Recent Development for Stereoselective Synthesis of 1,3-Polyol Ye Zhu Prof. Burgess’ Group Aug. 19, 2010.

(-)-Kendomycin Angew. Chem. Int. Ed. 2009,48,()

Enantioselective Total Synthesis of Ecteinascidin 743

Merocyanine dyes Synthesis, properties, application

Lactacystin: An Inhibitor in the Ubiquitin Proteasome Pathway Ami Jun-Yee Chin February 17, 2005.

Synthesis of Gelsemine Alexander J. L. Clemens Burke Group October 26, 2006.

Silas P. Cook Education: B.A. Reed College (1999);

Aza-Prins Cyclization

Enantioselective Total Synthesis of (+)-Gliocladin C and (+)-Gliocladine C 石枫 Larry E. Overman, Org. Lett., 2007, 9, 339 Larry E. Overman, J.

Chiral Concave N-Heterocyclic Carbenes 3 rd International Summer School “Supramolecular Systems in Chemistry and Biology“ Tim Reimers Kiel, GER.

Enantioselective Total Syntheses of Manzamine A and Related Alkaloids John M. Humphrey, Yusheng Liao, Amjad Ali, Tobias Rein, Yue-Ling Wong, Hui-Ju Chen,

Total Synthesis of (+)-Discodermolide CHEM635 Kelsey Roberts Group B February 19, 2013 Patterson, I*; Florence, G. J.; Gerlach, K.; Scott, J. P. Agnew.

Total Synthesis of Brevenal Jon D. Rainier Department of Chemistry, University of Utah. J. Am. Chem. Soc. 2011, 133, 3208–3216.

Welwitindolinones Tiffany Piou Group meeting

Synthesis and Biological Activity of Platensimycin

Synthesis directed towards Agelasines, Agelasimines, Asmarines and Analogs; Bioactive Marine Natural Products Lise-Lotte Gundersen Department of Chemistry,

Enantioselective Total Synthesis and Structure Revision of Spirodihydrobenzofuranlactam 1. Total Synthesis of Stachybotrylactam Org. Lett. 2003, 5, 1785.

Total Synthesis of Communesins Jian-Zhou Huang

Lecture 27 Special Topics - Drug Discovery: Synthetic Research: Natural Product Isolation Molecular Modification Anesthetics This Week in Lab: Spec Unknown.

Total Synthesis of Zoanthamine Alkaloids

Litterature Meeting Enantioselective Total Synthesis of Avrainvillamide and Stephacidins A and B Aspergillus ochraceus.

Kang Hyun Jung. Introduction Leucascandrolide A (1, Scheme 1) was isolated in 1996 from the calcareous sponge Leucascandra caveolata, collected off the.

Synthesis of meso-substituted porphyrins

Utilization of Ring Closing Metathesis in Alkaloid Synthesis I. Synthetic Studies on the Immunosuppressant FR II. Toward the Total Synthesis of Lundurines.

Synthesis of Leucascandrolide A via a Spontaneous Macrolactolization J. Am. Chem. Soc. 2002, 124, Presented by Vijayarajan Devannah 3/19/2013.

Jean-Louis Brochu Department of Chemistry University of Ottawa

A New Stereocontrolled Total Synthesis of the Mast Cell Inhibitory Alkaloid (+)-Monanchorin KarlJ.Hale* and Liping Wang. Org. Lett., 2014, 16 (7), xxxx.

Peter Yates ( ) B.Sc from the University of London, 1946.

Synthesis Making molecules you want from the ones you have.

Synthesis of Discodermolides Useful for Investigating Microtubule Binding and Stabilization Melissa G. Morris CHEM 635 February 12, 2013 Hung, D. T.; Nerenberg,

Enantioselective Total Synthesis of (-)-Strychnine

Michael J. Krische B.S.in Chemistry from University of California at Berkeley (1989) Fulbright Fellow at Helsinki University (1990) Ph.D. in Chemistry.

Rychnovsky’s Formal Synthesis of Leucascandrolide A Presented by BriAnne Bentivegna March 19, 2013 University of Delaware Kopecky, D.J.; Rychnovsky, S.D.

Nicolas Gaeng Group seminar – LSPN – 30/04/15. Structures with multiple rings connected through one atom Nomenclature proposed by Adolf Baeyer in 1900.

Carbonylative Polymerization of Propylene Oxide: A Multicatalytic Approach to the Synthesis of Poly(3-Hydroxybutyrate) Erin W. Dunn and Geoffrey W. Coates*

Progress towards the Synthesis of 1-Benzoxepin; A Model Oxepin Substrate Ian Smith, Ryan Fitzgerald, Holly Guevara, Arthur Greenberg

Escuela de Ciencias de la Salud Universidad Autónoma de Baja California Group Meeting Presentation Jesus Cordova Guerrero Olson Research Group January.

Total Synthesis of Linoxepin through a Palladium-Catalyzed Domino Reaction Lutz F. Tietze Angew. Chem. Int. Ed. 2013, 52, 3191–3194 Speaker: 王湘閔.

Enantioselective Total Synthesis of Plectosphaeroic acid B J. Am. Chem. Soc. 2013, 133, 6549−6552 Salman Y. Jabri and Larry E. Overman* Speaker: 古宜加.

Total Synthesis of (—)-Acetylaranotin Hideto Fujiwara, Taichi Kurogi, Shun Okaya, Kentaro Okano, and Hidetoshi Tokuyama* Angew. Chem. Int. Ed. 2012, 51,

Total Synthesis of Manzamine A and Related Alkaloids

Synthesis of Daphnilongeranine C

Group Meeting Presentation Reports on the Total Synthesis of Ibogaine

Zhengren Xu, Qian Wang, and Jieping Zhu*

Special Topic Presentation: Synthesis of Bis-piperidine Alkaloids

Low-Valent Iron-Catalyzed Transformations of Unsaturated Hydrocarbons

(Advisor : Prof. Eric N. Jacobsen)

Total Synthesis of the Potent cAMP Signaling Agonist (–)-Alotaketal A

Total Synthesis of (±)-Cylindricine C

Literature Meeting February, 7th, 2005 Jean-Manuel Cloarec

Recent Progress of Selective Monohydrolysis of Symmetric Diesters

Enantioselective Total Synthesis of (+)-Gelsemine

Synthetic Routes.

Ke Kong, John A. Enquist, Jr. , Monica E. McCallum, Genessa M

C-H Insertion of Rhodium-Carbene Using Diazo Compounds

Generation, Study, and Application of Dicationic Intermediates

crambescidin 800, crambescidin 359,

Total Synthesis of (±)-Indolizomycin

Kiyoun Lee and Dale L. Boger*

Enantioselective, Palladium-Catalyzed α-Arylation of N-Boc-pyrrolidine

DIVERGENT TOTAL SYNTHESES OF LYCONADINS A AND C

1. Palladium Catalyzed Organic Transformations

Presentation transcript:

Total Synthesis of Aplyviolene M. J. Schnermann and L. E. Overman, J. Am. Chem. Soc. 2011, 133, 16425-16427.

Total Synthesis of Aplyviolene Isolated from the marine sponge Dendrilla sp. in the Palau marine lakes Unknown biological activity ] B. Sullivan and D. J. Faulkner, J. Org. Chem. 1984, 49, 3204-3206.

Total Synthesis of Aplyviolene J. S. Buckleton, P. R. Bergquist, R. C. Cambie, G. R. Clark, P. Karuso and C. E. F. Rickard, Acta Cryst. 1986, 42, 1846-1848.

Retrosynthetic Analysis - Synthesized in 14 steps from A in 5.6% overall yield - A synthesized in 11 steps from 3-methyl-2-cyclohexenone in 19% overall yield A. D. Lebsack, L. E. Overman and R. J. Valentekovich, J. Am. Chem. Soc. 2001, 123, 4851-4852. M. J. Schnermann, C. M. Beaudry, A. V. Egorova, R. S. Polishchuk, C. Sütterlin and L. E. Overman, PNAS 2010, 107, 6158-6163. M. J. Schnermann, C. M. Beaudry, N. E. Genung, S. M. Canham, N. L. Untiedt, B. D. W. Karanikolas, C. Sütterlin and L. E. Overman, J. Am. Chem. Soc. 2011, 133, 17494-17503.

S. V. Ley, D. J. Dixon, R. T. Guy, F. Rodriguez and T. D. Sheppard, Org. Biomol. Chem. 2005, 3, 4095-4097.