Computational Fluid Dynamics and Aortic Thrombus Formation Following Thoracic Endovascular Aortic Repair  Foeke J.H. Nauta, MD, PhD, Kevin D. Lau, PhD,

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Computational Fluid Dynamics and Aortic Thrombus Formation Following Thoracic Endovascular Aortic Repair  Foeke J.H. Nauta, MD, PhD, Kevin D. Lau, PhD, Christopher J. Arthurs, PhD, Kim A. Eagle, MD, David M. Williams, MD, Santi Trimarchi, MD, PhD, Himanshu J. Patel, MD, Carlos A. Figueroa, PhD  The Annals of Thoracic Surgery  Volume 103, Issue 6, Pages 1914-1921 (June 2017) DOI: 10.1016/j.athoracsur.2016.09.067 Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Patient history showing (A) ascending aortic aneurysm which was repaired with a (B) surgical graft in 2012. (C) Paraanastomosis aneurysm dilatation 3 years postoperatively, which was treated with (D) TEVAR in December 2015. (E) Computed tomography angiography 1 month post-TEVAR suggested intraluminal thrombus at the proximal endograft end, as indicated by the red circle. (F) Magnetic resonance imaging confirmed ascending aortic thrombus, as marked by the red circle. The kink in the endograft is denoted with the blue circle. (TEVAR = thoracic endovascular aortic repair.) The Annals of Thoracic Surgery 2017 103, 1914-1921DOI: (10.1016/j.athoracsur.2016.09.067) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Models of the different aortic geometries. From left to right: the baseline aortic geometry, the ascending aortic surgical repair, the conformable endograft, and the single-branched endograft into the LSA. (LSA = left subclavian artery.) The Annals of Thoracic Surgery 2017 103, 1914-1921DOI: (10.1016/j.athoracsur.2016.09.067) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Pressure (black lines) and flow waveforms (red lines) computed at thoracic aorta inflow and different branch outlets. The location of each measurement is denoted by a number. The Annals of Thoracic Surgery 2017 103, 1914-1921DOI: (10.1016/j.athoracsur.2016.09.067) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 (A) Computed tomography imaging showing the aortic thrombus (red circle). (B–E) Particles and their corresponding PLAP value are shown at the end of the second cardiac cycle. Average PLAP are given for each model for both the aortic arch ROI (denoted within the two dashed lines) as well as for the thrombus location ROI (marked with a black circle). (B) Baseline aortic geometry, (C) aortic surgical repair, (D) conformable endograft, and (E) single-branched endograft. One-way analysis of variance testing calculated p < 0.001 for PLAP differences among the four models in both ROI. See the Video for a dynamic visualization of PLAP in each model. Values are presented as mean ± SD. (PLAP = platelet activation potential; ROI = region of interest.) The Annals of Thoracic Surgery 2017 103, 1914-1921DOI: (10.1016/j.athoracsur.2016.09.067) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Computed tomography at baseline and at 18 weeks follow-up demonstrating stable three-dimensional volumes of the intraaortic thrombus. The Annals of Thoracic Surgery 2017 103, 1914-1921DOI: (10.1016/j.athoracsur.2016.09.067) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions