Association of adverse birth outcomes with prenatal exposure to vanadium: a population-based cohort study  Jie Hu, PhD, Wei Xia, PhD, Xinyun Pan, MPH, Prof Tongzhang Zheng, PhD, Bin Zhang, PhD, Aifen Zhou, PhD, Prof Stephen L Buka, ScD, Bryan A Bassig, PhD, Wenyu Liu, MD, Chuansha Wu, MD, Yang Peng, MD, Jun Li, PhD, Chuncao Zhang, MPH, Hongxiu Liu, MD, Minmin Jiang, MD, Prof Youjie Wang, PhD, Jianduan Zhang, PhD, Zheng Huang, PhD, Dan Zheng, PhD, Kunchong Shi, PhD, Prof Zhengmin Qian, PhD, Prof Yuanyuan Li, PhD, Prof Shunqing Xu, PhD  The Lancet Planetary Health  Volume 1, Issue 6, Pages e230-e241 (September 2017) DOI: 10.1016/S2542-5196(17)30094-3 Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Terms and Conditions

Figure Dose-response relationships between maternal urinary vanadium concentrations and the risk of adverse birth outcomes Graphs show the OR (solid lines; 95% CI [dotted lines]) of association of Ln-vanadium concentrations (corrected for creatinine concentration) with the risk of preterm delivery (A); early-term delivery (B); low birthweight (C); term, low birthweight (D); preterm, low birthweight (E); small for gestational age (<10%; F); light-small for gestational age (5–9%; G); and severe-small for gestational age (<5%; H). ORs from final models were adjusted for maternal age at delivery, parity, pre-pregnancy body-mass index, active smoking, passive smoking, hypertensive disorders in pregnancy, gestational diabetes, education, and infant sex. Bars show the distribution of Ln-vanadium concentrations. Ln-vanadium=natural logarithm transformed urinary concentrations of vanadium, corrected for creatinine concentration. OR=odds ratio. The Lancet Planetary Health 2017 1, e230-e241DOI: (10.1016/S2542-5196(17)30094-3) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Terms and Conditions