Shedding “UV” Light on Endogenous Opioid Dependence

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Presentation transcript:

Shedding “UV” Light on Endogenous Opioid Dependence Hugo A. Tejeda, Antonello Bonci Cell Volume 157, Issue 7, Pages 1500-1501 (June 2014) DOI: 10.1016/j.cell.2014.06.009 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Working Model of Endogenous Opioid Dependence Produced by Chronic UV Light Exposure UV light increases p53 signaling in keratinocytes. Keratinocyte p53 signaling increases the synthesis of POMC propeptide. POMC is processed to yield β-endorphin and other biologically active peptides. Sustained increases in plasma β-endorphin increases signaling at opioid receptors in the periphery and/or central nervous system to produce an endogenous opioid-dependent state. Opioid receptor signaling may alter the neural activity of midbrain dopamine neurons in the ventral tegmental area (VTA) to produce elevations of dopamine in reward-related regions, including the nucleus accumbens (NAcc) or the prefrontal cortex (PFC). This endogenous opioid-dependent state may underlie the addictive properties of UV bed or sun tanning and may potentially be utilized to treat psychiatric disorders. Cell 2014 157, 1500-1501DOI: (10.1016/j.cell.2014.06.009) Copyright © 2014 Elsevier Inc. Terms and Conditions