Figure 1 Influence of diet on gut microbiota and blood pressure

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Presentation transcript:

Figure 1 Influence of diet on gut microbiota and blood pressure Figure 1 | Influence of diet on gut microbiota and blood pressure. Dietary fibre is mostly undigested until it reaches the colon, where it feeds commensal bacteria, decreasing the proliferation of pathogenic bacteria. The fermentation of fibre generates short-chain fatty acids (SCFAs). Acetate, propionate, and butyrate account for 80% of the SCFAs produced by the microbiota, found in roughly 60:25:15 ratios, respectively, within the colon. Butyrate is used by colonocytes to maintain the intestinal barrier and decrease local inflammation, but small amounts are transported with acetate and propionate to the liver through the portal vein. Propionate is metabolised by the hepatocytes, whereas acetate and smaller proportions of propionate and butyrate are released into the systemic circulation, where they can reach organs involved in the regulation of blood pressure. Marques, F. Z. et al. (2017) Beyond gut feelings: how the gut microbiota regulates blood pressure Nat. Rev. Cardiol. doi:10.1038/nrcardio.2017.120