A New Handle for a Hot Topic: Genetic Markers for Warm-Sensing

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A New Handle for a Hot Topic: Genetic Markers for Warm-Sensing Gillian A. Matthews, Kay M. Tye Cell Volume 167, Issue 1, Pages 43-44 (September 2016) DOI: 10.1016/j.cell.2016.09.016 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Characterizing Temperature-Sensitive Neurons and Their Role in Thermoregulation (A) Warm-sensitive neurons were identified using “phosphoTRAP.” Mice were subjected to environmental warmth followed by molecular profiling of activated (pS6+) neurons. This revealed a largely overlapping population of PACAP/BDNF+ neurons in the ventromedial preoptic area (VMPO), the majority of which were pS6+. (B) Model indicating how the VMPOPACAP/BDNF neurons may integrate peripheral sensory temperature information and orchestrate a reduction in core body temperature via multiple downstream effector systems. Cell 2016 167, 43-44DOI: (10.1016/j.cell.2016.09.016) Copyright © 2016 Elsevier Inc. Terms and Conditions