KIT D816V–associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA- associated chronic eosinophilic leukemia are distinct entities Irina Maric,

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Presentation transcript:

KIT D816V–associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA- associated chronic eosinophilic leukemia are distinct entities Irina Maric, MD, Jamie Robyn, MD, PhD, Dean D. Metcalfe, MD, Michael P. Fay, PhD, Melody Carter, MD, Todd Wilson, DO, Weiming Fu, MD, Jennifer Stoddard, Linda Scott, Marilyn Hartsell, Arnold Kirshenbaum, MD, Cem Akin, MD, PhD, Thomas B. Nutman, MD, Pierre Noel, MD, Amy D. Klion, MD Journal of Allergy and Clinical Immunology Volume 120, Issue 3, Pages 680-687 (September 2007) DOI: 10.1016/j.jaci.2007.05.024 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Plot of total serum tryptase versus peak absolute eosinophil counts (AEC) for patients with FIP1L1/PDGFRA-CEL (squares) and SM-eo (triangles). Journal of Allergy and Clinical Immunology 2007 120, 680-687DOI: (10.1016/j.jaci.2007.05.024) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Bone marrow histological findings in SM-eo and CEL. Dense mast cell aggregates are seen in all SM-eo specimens by tryptase immunohistochemical staining (IHS), whereas scattered spindle-shaped mast cells forming loose collections are usually seen in the CEL specimens. Magnification ×100. H&E, Hematoxylin and eosin. Journal of Allergy and Clinical Immunology 2007 120, 680-687DOI: (10.1016/j.jaci.2007.05.024) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions