KIT D816V–associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA- associated chronic eosinophilic leukemia are distinct entities  Irina Maric,

Slides:



Advertisements
Similar presentations
A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,
Advertisements

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.
D-dimer: A biomarker for antihistamine-resistant chronic urticaria
Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS 
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 
Allergen immunotherapy: A practice parameter third update
Adult-onset systemic mastocytosis in monozygotic twins with KIT D816V and JAK2 V617F mutations  Sigurd Broesby-Olsen, MD, Thomas Kielsgaard Kristensen,
Clarification concerning amoxicillin skin testing
Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with.
Edwin A. McElroy, M.D., Robert L. Phyliky, M.D., Chin-Yang Li, M.D. 
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
Expression of PD-L1 in mastocytosis
Stephen J. Fowler, MD, Gaël Tavernier, PhD, Robert Niven, MD 
Histologic eosinophilic gastritis is a systemic disorder associated with blood and extragastric eosinophilia, TH2 immunity, and a unique gastric transcriptome 
Is 9 more than 2 also in allergic airway inflammation?
Desensitization to Chemotherapeutic Agents
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 
Pathergy response to skin prick testing
IL-5 receptor α levels in patients with marked eosinophilia or mastocytosis  Todd M. Wilson, DO, Irina Maric, MD, Juhi Shukla, MSc, Margaret Brown, BS,
Solitary mastocytoma in an adult with an unusual clinical presentation
Silvana Balzar, MD, Matthew Strand, PhD, Diane Rhodes, PhD, Sally E
Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J
Mastocytosis associated with a rare germline KIT K509I mutation displays a well- differentiated mast cell phenotype  Eunice Ching Chan, PhD, Yun Bai, MSc,
Eosinophilia in systemic mastocytosis: Clinical and molecular correlates and prognostic significance  Alexandra Böhm, MD, Manuela Födinger, MD, Friedrich.
Polyethylene glycol–modified adenosine deaminase improved lung disease but not liver disease in partial adenosine deaminase deficiency  Raz Somech, MD,
Nonadherence to Asthma Treatment: Getting Unstuck
Mast cell activation syndrome: Proposed diagnostic criteria
Repeated Episodes of Anaphylaxis with Normal Serum Tryptase but Elevated Levels of Urinary Prostaglandin D2  Phillip Lieberman, MD  The Journal of Allergy.
Clonal mast cell disorders in patients with systemic reactions to Hymenoptera stings and increased serum tryptase levels  Patrizia Bonadonna, MD, Omar.
Serum tryptase levels in atopic and nonatopic children
A survivor: The eosinophil as a regulator in asthma
A distinct biomolecular profile identifies monoclonal mast cell disorders in patients with idiopathic anaphylaxis  Melody C. Carter, MD, Avanti Desai,
Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation  Leif Bjermer, MD  Journal of Allergy.
Serum free light chains in the differential diagnosis and prognosis of primary and secondary hypogammaglobulinemia  Nicolò Compagno, MD, Francesco Cinetto,
The role of the mast cell in the pathophysiology of asthma
Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management  Scott H. Sicherer, MD, Hugh A. Sampson, MD  Journal.
Biosimilars and drug development in allergic and immunologic diseases
Anaphylactic Reaction to White-Faced Hornet Sting and Elevated Baseline (Asymptomatic) Serum Tryptase  Phillip Lieberman, MD, Lawrence B. Schwartz, MD,
Oral administration of a synthetic agonist of Toll-like receptor 9 potently modulates peanut-induced allergy in mice  Fu-Gang Zhu, PhD, Ekambar R. Kandimalla,
Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS 
CC chemokine receptors CCR1 and CCR4 are expressed on airway mast cells in allergic asthma  Kawa Amin, PhD, Christer Janson, MD, PhD, Ilkka Harvima, MD,
What is an “eosinophilic phenotype” of asthma?
Assessment of clinical findings, tryptase levels, and bone marrow histopathology in the management of pediatric mastocytosis  Melody C. Carter, MD, Sarah.
Autophagy: Nobel Prize 2016 and allergy and asthma research
Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment
Advances in the approach to the patient with food allergy
Successful haploidentical bone marrow transplantation in a patient with reticular dysgenesis: Three-year follow-up  Meredith Lee Heltzer, MD, Michele.
New pathways for itching in patients with atopic dermatitis?
The gastrointestinal tract is critical to the pathogenesis of acute HIV-1 infection  Saurabh Mehandru, MD, Klara Tenner-Racz, MD, Paul Racz, MD, PhD, Martin.
One step forward, 2 steps back: The enigma of preschool wheeze
Analysis of the lineage relationship between mast cells and basophils using the c-kit D816V mutation as a biologic signature  Can N. Kocabas, MD, Akif.
Benjamin Chaigne, MD, Hervé Watier, MD, PhD 
Eosinophilic esophagitis treated with immunotherapy to dust mites
Rebound eosinophilia after treatment of hypereosinophilic syndrome and eosinophilic gastroenteritis with monoclonal anti–IL-5 antibody SCH55700  Yae-Jean.
Anaphylaxis Journal of Allergy and Clinical Immunology
Esophageal eosinophilia caused by milk proteins: From suspicion to evidence based on 2 case reports  Soledad Terrados Cepeda, MD, Dario Antolin-Amerigo,
Eyal Grunebaum, MD, Ernest Cutz, MD, Chaim M. Roifman, MD 
Measles and immunomodulation
IL-9 and c-Kit+ mast cells in allergic rhinitis during seasonal allergen exposure: Effect of immunotherapy  Kayhan T. Nouri-Aria, PhD, FRCPath, Charles.
Macrolide antibiotics and asthma treatment
Asthma: The past, future, environment, and costs
Charles W. DeBrosse, MD, Margaret H. Collins, MD, Bridget K
Environmental factors and eosinophilic esophagitis
Systemic responses after bronchial aspirin challenge in sensitive patients with asthma  Joanna S. Makowska, MD, PhD, Janina Grzegorczyk, PhD, Barbara Bienkiewicz,
The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy  Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.
Natural history of cow’s milk allergy
Differences in airway remodeling between subjects with severe and moderate asthma  Carmela Pepe, MD, Susan Foley, MD, Joanne Shannon, MD, Catherine Lemiere,
Primary prevention of asthma and allergy
Chitinases and chitinase-like proteins in TH2 inflammation and asthma
Advances in mechanisms of allergic disease in 2016
Presentation transcript:

KIT D816V–associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA- associated chronic eosinophilic leukemia are distinct entities  Irina Maric, MD, Jamie Robyn, MD, PhD, Dean D. Metcalfe, MD, Michael P. Fay, PhD, Melody Carter, MD, Todd Wilson, DO, Weiming Fu, MD, Jennifer Stoddard, Linda Scott, Marilyn Hartsell, Arnold Kirshenbaum, MD, Cem Akin, MD, PhD, Thomas B. Nutman, MD, Pierre Noel, MD, Amy D. Klion, MD  Journal of Allergy and Clinical Immunology  Volume 120, Issue 3, Pages 680-687 (September 2007) DOI: 10.1016/j.jaci.2007.05.024 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Plot of total serum tryptase versus peak absolute eosinophil counts (AEC) for patients with FIP1L1/PDGFRA-CEL (squares) and SM-eo (triangles). Journal of Allergy and Clinical Immunology 2007 120, 680-687DOI: (10.1016/j.jaci.2007.05.024) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Bone marrow histological findings in SM-eo and CEL. Dense mast cell aggregates are seen in all SM-eo specimens by tryptase immunohistochemical staining (IHS), whereas scattered spindle-shaped mast cells forming loose collections are usually seen in the CEL specimens. Magnification ×100. H&E, Hematoxylin and eosin. Journal of Allergy and Clinical Immunology 2007 120, 680-687DOI: (10.1016/j.jaci.2007.05.024) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions