Amyloid Cascade into Clarity

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Amyloid Cascade into Clarity Tara M. Weitz, Terrence Town  Immunity  Volume 45, Issue 4, Pages 717-718 (October 2016) DOI: 10.1016/j.immuni.2016.10.006 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Targeting Mononuclear Phagocytes for Amyloid Clearance with Aβ Immunotherapy In response to aducanumab, mononuclear phagocytes (hematagenous macrophages or brain-resident microglia) home to and phagocytose pathogenic Aβ. In Alzheimer’s disease (AD), brain mononuclear phagocytes have repressed phagocytosis, favoring Aβ accumulation and neurotoxicity. Immunity 2016 45, 717-718DOI: (10.1016/j.immuni.2016.10.006) Copyright © 2016 Elsevier Inc. Terms and Conditions

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