Similar Transplantation Outcomes for Acute Myeloid Leukemia and Myelodysplastic Syndrome Patients with Haploidentical versus 10/10 Human Leukocyte Antigen–

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Presentation transcript:

Similar Transplantation Outcomes for Acute Myeloid Leukemia and Myelodysplastic Syndrome Patients with Haploidentical versus 10/10 Human Leukocyte Antigen– Matched Unrelated and Related Donors Antonio Di Stasi, Denái R. Milton, L.M. Poon, Amir Hamdi, Gabriela Rondon, Julianne Chen, Sai R. Pingali, Marina Konopleva, Piyanuch Kongtim, Amin Alousi, Muzaffar H. Qazilbash, Sairah Ahmed, Qaiser Bashir, Gheath Al-atrash, Betul Oran, Chitra M. Hosing, Partow Kebriaei, Uday Popat, Elizabeth J. Shpall, Dean A. Lee, Marcos de Lima, Katayoun Rezvani, Issa F. Khouri, Richard E. Champlin, Stefan O. Ciurea Biology of Blood and Marrow Transplantation Volume 20, Issue 12, Pages 1975-1981 (December 2014) DOI: 10.1016/j.bbmt.2014.08.013 Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Transplantation outcomes for recipients of haploidentical, matched related, and 10/10 HLA–matched unrelated donor transplantations. (A) All treated patients and (B) patients in remission at transplantation. Progression-free survival (PFS), overall survival (OS), and cumulative incidence of nonrelapse mortality (NRM) are shown. (C) Multivariable analysis for PFS for patients in remission before transplantation, in relation to age, cytogenetic risk (SWOG), melphalan dose, donor type (matched versus haploidentical), and hematopoietic stem cell comorbidity index. Biology of Blood and Marrow Transplantation 2014 20, 1975-1981DOI: (10.1016/j.bbmt.2014.08.013) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Recovery of T cell subsets for recipients of haploidentical, matched sibling, and 10/10 HLA–matched unrelated donor transplantations. Median number of T lymphocyte subsets, B cells (CD20+) and natural killer cells (CD3negCD56+) are shown for each donor type (horizontal lines indicate reference values), and table displays range value. Biology of Blood and Marrow Transplantation 2014 20, 1975-1981DOI: (10.1016/j.bbmt.2014.08.013) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions