Y-chromosome AZFc structural architecture and relationship to male fertility  Celia Ravel, M.D., Ph.D., Sandra Chantot-Bastaraud, M.D., Ph.D., Brahim El Houate, Ph.D., Hassan Rouba, Ph.D., Marie Legendre, M.D., Ph.D., Diana Lorenço, Ph.D., Jacqueline Mandelbaum, M.D., Ph.D., Jean Pierre Siffroi, M.D., Ph.D., Ken McElreavey, Ph.D.  Fertility and Sterility  Volume 92, Issue 6, Pages 1924-1933 (December 2009) DOI: 10.1016/j.fertnstert.2008.08.135 Copyright © 2009 Terms and Conditions

Figure 1 Representative polymerase chain reaction amplifications for evaluation DAZ copy number. DAZL and DAZ specific fragments are indicated. Control samples C2, C4, and C6 are shown together with several examples of amplifications from case and control samples. M, molecular-weight ladder. Fertility and Sterility 2009 92, 1924-1933DOI: (10.1016/j.fertnstert.2008.08.135) Copyright © 2009 Terms and Conditions

Figure 2 Schematic representations of the AZFc region structural architecture. Seven AZFc chromosome structures are shown that can explain all the deletion classes observed in the case and control samples. The reference AZFc sequence is indicated, and the organization of amplicons belonging to various families are shown in colors (b1 to b4, blue; r1 to r4, red; g1 to g3, green). Two small palindromes, P1.1 and P1.2 (yellow), lie within a larger P1 palindrome. Sequences with the same color code exhibit >99.9% sequence identity. The relative location of CDY1 and DAZ gene copies and the STS markers used in this study are indicated underneath their respective amplicons. Fertility and Sterility 2009 92, 1924-1933DOI: (10.1016/j.fertnstert.2008.08.135) Copyright © 2009 Terms and Conditions