European Urology Oncology Patient-reported Outcomes Following Treatment of Localised Prostate Cancer and Their Association with Regret About Treatment Choices  Marie-Anne van Stam, Neil K. Aaronson, J.L.H. Ruud Bosch, Jacobien M. Kieffer, Jochem R.N. van der Voort van Zyp, Corinne N. Tillier, Simon Horenblas, Henk G. van der Poel  European Urology Oncology  DOI: 10.1016/j.euo.2018.12.004 Copyright © 2018 European Association of Urology Terms and Conditions

Fig. 1 Recruitment, treatment, and follow-up. Patient-reported treatment information. aThe analytic cohort included those men who were diagnosed with a cT1 or cT2 tumour, started one of the four management strategies of interest, and completed the baseline questionnaire and at least one follow-up assessment. bSurgical technique: 186 robot-assisted laproscopic; prostatectomy; 5 open prostatectomy. European Urology Oncology DOI: (10.1016/j.euo.2018.12.004) Copyright © 2018 European Association of Urology Terms and Conditions

Fig. 2 Association between initial treatment of prostate cancer and patient-reported outcomes. Higher scores indicate more symptoms or more distress. Data in the graphs are adjusted mean scores estimated by multivariable models that controlled for baseline domain score, age, comorbidity, and prostate cancer risk group. Supplementary Tables 2 and 3 contain unadjusted domain scores and number of patients for each subgroup by treatment. The purple shaded areas indicate the 99% confidence interval of the reference group (AS). For all scales except the Decision Regret Scale, baseline is defined as the mean baseline score of all patients included in the main analyses; a distinction between ER+ and ER− is made only when we observed significant differences between the ER subgroups (Supplementary Table 3); only pretreatment responses of patients who initially started active surveillance but changed to active treatment during follow-up were included in the analyses. AS=active surveillance; ASdisc.=changed to active treatment during active surveillance follow-up; BT=brachytherapy; CI=confidence interval; ER=external beam radiotherapy (with and without androgen deprivation therapy); ER+=external beam radiotherapy with androgen deprivation therapy; ER−=external beam radiotherapy without androgen deprivation therapy; RP=radical prostatectomy. European Urology Oncology DOI: (10.1016/j.euo.2018.12.004) Copyright © 2018 European Association of Urology Terms and Conditions