Cancer Genomes Evolve by Pulverizing Single Chromosomes

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Cancer Genomes Evolve by Pulverizing Single Chromosomes Matthew Meyerson, David Pellman Cell Volume 144, Issue 1, Pages 9-10 (January 2011) DOI: 10.1016/j.cell.2010.12.025 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Stitching Together Shattered Chromosomes by Chromothripsis Chromothripsis is proposed to involve the shattering of a single chromosome, a small group of chromosomes, or a single chromosome arm. The fragments, or a subset of the fragments, are then stitched together by nonhomologous end-joining. The mechanism by which these alterations are confined to a small segment of the genome is not defined. Cell 2011 144, 9-10DOI: (10.1016/j.cell.2010.12.025) Copyright © 2011 Elsevier Inc. Terms and Conditions