Evidence of a Graft-versus-Hodgkin Lymphoma Effect in the Setting of Extensive Bone Marrow Involvement Paolo Anderlini, MD Biology of Blood and Marrow.

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Evidence of a Graft-versus-Hodgkin Lymphoma Effect in the Setting of Extensive Bone Marrow Involvement Paolo Anderlini, MD Biology of Blood and Marrow Transplantation Volume 14, Issue 4, Pages 478-480 (April 2008) DOI: 10.1016/j.bbmt.2007.12.496 Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 (A, left) This displays the May 11, 2007, positron-emission tomography (PET)-computed tomography (CT) scan showing recurrent disease with multiple, extensive PET-positive lesions throughout the skeleton, and retroperitoneal adenopathy. (B, right) This shows the August 1, 2007, PET-CT study showing complete resolution of the multifocal osseous as well as nodal lesions. PET scans were acquired following the intravenous injection of 16.9 mCi of 2-deoxy-2-[18F]fluoro-D-glucose (FDG), and noncontrast enhanced CT scans were acquired for attenuation, correction and, diagnosis. Biology of Blood and Marrow Transplantation 2008 14, 478-480DOI: (10.1016/j.bbmt.2007.12.496) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Bone marrow biopsy (A) showing Hodgkin cells (center) in a background of small lymphocytes, histiocytes, and marrow fibrosis. Original hematoxylin & eosin (H&E), ×500 magnification. Skin biopsy (B) showing necrotic keratinocytes (arrows) indicating cutaneous GVHD (original H&E stain, ×400 magnification). Transjugular liver biopsy (C and D) showing bile-duct damage with necrotic cholangiocytes (arrows) consistent with hepatic graft-versus-host disease (original H&E stain, ×400 magnification). Biology of Blood and Marrow Transplantation 2008 14, 478-480DOI: (10.1016/j.bbmt.2007.12.496) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions