Screening Solvent Effects in Anion Recognition Scott L. Cockroft  Chem  Volume 3, Issue 3, Pages 383-384 (September 2017) DOI: 10.1016/j.chempr.2017.08.008 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Experimental System Used by Flood and Co-workers to Quantify Solvent Effects on Anion Binding (A) Binding equilibrium for chloride with a neutral triazolophane host. (B) Dependency on the log of the association constant of binding (K1) on the dielectric constant of the solvent (εr). Two binding regimes are observed: one in which electrostatic interactions dominate the energetic trends (left) and another in which preferential solvation of the macrocyclic binding site by water cancels out residual interactions arising from van der Waals forces and inductive polarization (right). Blue circles represent experimental data that were initially predicted and subsequently shown to fit on the red correlation. Chem 2017 3, 383-384DOI: (10.1016/j.chempr.2017.08.008) Copyright © 2017 Elsevier Inc. Terms and Conditions