Does the Bicoid Gradient Matter?

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Does the Bicoid Gradient Matter? Siegfried Roth, Jeremy Lynch Cell Volume 149, Issue 3, Pages 511-512 (April 2012) DOI: 10.1016/j.cell.2012.04.007 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Activator and Repressor Gradients Cooperate for Differential Gene Expression Anterior target genes (cyan, yellow, and purple bars) integrate activating inputs from Bicoid (Bcd, blue) and repressive inputs from Runt (orange) and Capicua (not shown) in order to establish different posterior borders of expression in fruit fly embryos. Chen et al. (2012) shows that many anterior genes share a common activation threshold (AT) but respond to different repressive thresholds (RTN). Their work also indicates that the Runt gradient is generated through the action of one or more Bcd target genes (purple line). Cell 2012 149, 511-512DOI: (10.1016/j.cell.2012.04.007) Copyright © 2012 Elsevier Inc. Terms and Conditions