Histological analysis of tumours in PyMT mice with different levels of endotrophin after chemotherapy.A.Endotrophin staining and quantification, showing.

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Histological analysis of tumours in PyMT mice with different levels of endotrophin after chemotherapy.A.Endotrophin staining and quantification, showing increased endotrophin levels upon cisplatin treatment which was further augmented in PyMT/endotrophin mice, whereas it was barely detectable in PyMT/TZD and PyMT/COL6−/− mice. **p = 0.0174, ##p = 0.009, #p = 0.024 and ###p = 0.0004.B.H&E staining and necrotic lesion area quantification on tumours, showing increased cell death after cisplatin treatment in all groups, and further augmented sensitivity in PyMT/TZD. *p = 0.0463.C.E‐cadherin staining and quantification, showing decreased membrane integrity of epithelial cancer cells after cisplatin treatment in PyMT mice. Histological analysis of tumours in PyMT mice with different levels of endotrophin after chemotherapy.A.Endotrophin staining and quantification, showing increased endotrophin levels upon cisplatin treatment which was further augmented in PyMT/endotrophin mice, whereas it was barely detectable in PyMT/TZD and PyMT/COL6−/− mice. **p = 0.0174, ##p = 0.009, #p = 0.024 and ###p = 0.0004.B.H&E staining and necrotic lesion area quantification on tumours, showing increased cell death after cisplatin treatment in all groups, and further augmented sensitivity in PyMT/TZD. *p = 0.0463.C.E‐cadherin staining and quantification, showing decreased membrane integrity of epithelial cancer cells after cisplatin treatment in PyMT mice. TZD reverses cisplatin‐induced loss of E‐cadherin levels. **p = 0.0045 and #p = 0.0285.D.Vimentin staining and quantification, showing increased EMT in PyMT/endotrophin mice, whereas it was decreased in PyMT/TZD and PyMT/COL6−/− mice. **p = 0.0085 and #p = 0.0111. Quantified results represent mean ± SD (multiple images from n = 5–6/group). Statistics (*PBS vs. CIS; #CIS vs. ETP/CIS, TZD/CIS, or COL6−/−/CIS) were analysed by unpaired Student's t‐test. Scales: 50 µm (A), 200 µm (B) and 100 µm (C–D).E.Hypothetical modeling of cisplatin responsiveness in PyMT mice relying on the endotrophin levels and EMT status. Arrow indicates TZD augments chemo‐sensitivity through suppression of endotrophin levels and EMT. Jiyoung Park et al. EMBO Mol Med. 2013;5:935-948 © as stated in the article, figure or figure legend