Prospective evaluation and clinical utility of on-site monitoring of coagulation in patients undergoing cardiac operation G.J. Despotis, MDa, S.A. Santoro,

Slides:

Advertisements

Similar presentations

Objective assessment of gastroesophageal reflux after short esophagomyotomy for achalasia with the use of manometry and pH monitoring John M. Streitz,

Advertisements

The additional hospital costs generated in the management of complications of pacemaker and defibrillator implantations T.Bruce Ferguson, MD, Candice Lilley.

Peter E. Ballmer, MDa, Walter H

Clinical evaluation of recombinant human platelet – derived growth factor for the treatment of lower extremity diabetic ulcers David L. Steed, MD, the.

Activation of coagulation and fibrinolytic pathways in patients with left ventricular assist devices Talia Spanier, MDa, Mehmet Oz, MDa, Howard Levin,

Influence of normothermic systemic perfusion during coronary artery bypass operations: A randomized prospective study Inderpaul Birdi, FRCS, Idris Regragui,

Blood Management Anesthesiology Clinics

Warfarin therapy does not increase bleeding in patients undergoing heart transplantation Cullen D Morris, MD, J.David Vega, MD, Jerrold H Levy, MD, Nancy.

Platelet-rich plasmapheresis in cardiac surgery: A meta-analysis of the effect on transfusion requirements F.D. Rubens, MDa, D. Fergusson, MHAb, P.S.

Yuji Hiramatsu, MDa, Nicolas Gikakis, BSEa, Harry L

Ralph J. Lewis, MD The Journal of Thoracic and Cardiovascular Surgery

Fibrinogen Levels After Cardiac Surgical Procedures: Association With Postoperative Bleeding, Trigger Values, and Target Values Marco Ranucci, MD, Valeria.

Reduced postoperative blood loss and transfusion requirement after beating-heart coronary operations: A prospective randomized study Raimondo Ascione,

Peter E. Ballmer, MDa, Walter H

Does steroid pretreatment increase endotoxin release during clinical cardiopulmonary bypass? Song Wan, MD, PhDa, Jean-Louis LeClerc, MDb, Chi-Hoang Huynh,

LiQian Chen, MD, PhD, Arthur W

Autologous Platelet-Rich Plasma Reduces Transfusions During Ascending Aortic Arch Repair: A Prospective, Randomized, Controlled Trial Shao Feng Zhou,

Optimizing selection of patients for major lung resection

Neel R. Sodha, MD, Frank W. Sellke, MD

The days of future past Neel K. Ranganath, MD, Aubrey C. Galloway, MD

James L. Cox, MD, Niv Ad, MD, Terry Palazzo, RN, MS

Retrospective analysis of the incidence of epidural haematoma in patients with epidural catheters and abnormal coagulation parameters P. Gulur, B. Tsui,

Routine use of viscoelastic blood tests for diagnosis and treatment of coagulopathic bleeding in cardiac surgery: updated systematic review and meta-analysis

Long-term survival benefits of coronary artery bypass grafting and percutaneous transluminal angioplasty in patients with coronary artery disease Robert.

Biocompatibility of heparin-coated extracorporeal bypass circuits: A randomized, masked clinical trial Derek D. Muehrcke, MDa, Patrick M. McCarthy, MDa,

The unintended consequences in clinical research

Richard J. Novick, MDa, Ruud A. W

Editorial: The core of leadership

Coagulation, fibrinolysis, and cell activation in patients and shed mediastinal blood during coronary artery bypass grafting with a new heparin-coated.

Kyle W. Riggs, MD, David L.S. Morales, MD

Whole blood heparin concentration measurements by automated protamine titration agree with plasma anti-Xa measurements G.J. Despotis, MD, J.H. Joist,

Support Your Specialty

Michele Gallo, MD, Gino Gerosa, MD

Coagulopathy and blood component transfusion in trauma

Thoracic Surgery Workforce Report

Switch back: Using the pulmonary autograft to replace the aortic valve after arterial switch operation Mark G. Hazekamp, MD, PhDa, Paul H. Schoof, MDa,

Frederick L. Grover, MDa, b, David J

Patient recovery after intermittent disc escape and spontaneous recession of a mechanical heart valve Francis Robicsek, MD, PhD, Joseph W. Cook, MD

Kai Ihnken, MD The Journal of Thoracic and Cardiovascular Surgery

Increase in size of the pulmonary autograft after the ross operation in children: Growth or dilation? Laszlo Solymar, MD, PhD, Göran Südow, MD, Daniel.

The Ross procedure: Time to reevaluate the guidelines

Ara K. Pridjian, MD, Edward L. Bove, MD, Flavian M. Lupinetti, MD

R. Pfitzmann, MD, M. Hummel, MD, O. Grauhan, MD, P. Waurick, MD, R

Elspeth M. Brown, MRCP, Anthony P. Salmon, FRCP, Robert K. Lamb, FRCS

John H. Lemmer, MDa, George J. Despotis, MDb

Transfusion outcomes in patients undergoing coronary artery bypass grafting treated with prasugrel or clopidogrel: TRITON-TIMI 38 retrospective data analysis

The limits of detectable cerebral perfusion by transcranial doppler sonography in neonates undergoing deep hypothermic low-flow cardiopulmonary bypass

Desensitization of myocardial β-adrenergic receptors and deterioration of left ventricular function after brain death Thomas A. D'Amico, MDa, Cary H.

Ralph S. Mosca, MD The Journal of Thoracic and Cardiovascular Surgery

P.K. Spanos, MD, A.D. Bisbos, MD, I.I. Arditis, MD

Multiple plexiform schwannomas in a patient with neurofibromatosis

Christopher E. Gates, MDa (by invitation), Carolyn E

Epinephrine absorption in children with a history of anaphylaxis

Human factors and cardiac surgery: A multicenter study

The Journal of Thoracic and Cardiovascular Surgery

Discussion The Journal of Thoracic and Cardiovascular Surgery

The future of cardiac surgery training: A survival guide

Efficacy of immunomodulation in the treatment of profound thrombocytopenia after adult cardiac surgery J. Scott Rankin, MD, Charles W. Stratton, MD

Erosion of inlet cannula of left ventricular assist device manifested as innocuous bleeding in stable patient: Lessons learned in prevention of catastrophic.

Improvement of myocardial mitochondrial function after hemodynamic support with left ventricular assist devices in patients with heart failure Sun Hi.

Thomas J. Kirby, MDa (by invitation), Michael J

Lung cancer randomized controlled trials should compare stereotactic body radiation therapy with observation, NOT surgery Raja M. Flores, MD The Journal.

Minimally invasive direct coronary artery bypass, percutaneous transluminal coronary angioplasty, and stent placement for left main stenosis William.

Desmopressin does not reduce bleeding and transfusion requirements in congenital heart operations William C Oliver, MD, Paula J Santrach, MD, Gordon.

Gastrointestinal bleeding after left ventricular assist device implantation: It is all about the platelets Juan A. Crestanello, MD The Journal of Thoracic.

The Impact of New Technology on Cardiothoracic Surgical Practice

Peter B. Manning, MD§, John E. Mayer, MD, Gil Wernovsky, MD§, Steven B

Y.John Gu, MD, PhD, Piet W. Boonstra, MD, PhD, Willem van Oeveren, PhD

S. Tabbutt, MD, PhDa b d e, B. W. Duncan, MDc f, D. McLaughlin, RNg, D

Thromboelastometry-guided administration of fibrinogen concentrate for the treatment of excessive intraoperative bleeding in thoracoabdominal aortic aneurysm.

Presentation transcript:

Prospective evaluation and clinical utility of on-site monitoring of coagulation in patients undergoing cardiac operation G.J. Despotis, MDa, S.A. Santoro, MD, PhDb, E. Spitznagel, PhDc, K.M. Kater, MSNd, J.L. Cox, MDe, P. Barnes, MT(ASCP)f, D.G. Lappas, MDg The Journal of Thoracic and Cardiovascular Surgery Volume 107, Issue 1, Pages 271-279 (January 1994) DOI: 10.5555/uri:pii:S0022522394704813 Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 1 The three arms of the transfusion algorithm are based on the initial platelet count. An initial platelet count of less than 50,000 (left arm: severe platelet deficiency) warrants platelet transfusion. If the initial platelet count was greater than 50,000 (middle and right arms), the PT; aPTT ratio values would delineate whether platelet therapy versus thawed plasma were administered. PT; aPTT ratio values were determined by dividing the whole blood PT and aPTT measurements by the mean value derived from a normal reference population of patients for each respective assay. Whole blood PT and aPTT were measured with the Biotrack 512 coagulation monitor. Platelet count (PLT Count), expressed in thousands, was measured with a Coulter T540 hemocytometer. Platelets, Platelet transfusion (6 random donor units); PLT RX, platelet therapy (6 random donor units or 0.3 mg/kg DDAVP at physician's discretion); FFP, 2 units of thawed plasma; [+] MVB, persistent microvascular bleeding. The Journal of Thoracic and Cardiovascular Surgery 1994 107, 271-279DOI: (10.5555/uri:pii:S0022522394704813) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 2 Varying prevalence of microvascular bleeding (MVB) corresponding to number of procedures, operative history, or both. Actual incidence of microvascular bleeding is denoted by the fractions within the parentheses ( ), whereas fractions within the brackets [ ] represent the calculated probability from logistic regression (see text for details). The Journal of Thoracic and Cardiovascular Surgery 1994 107, 271-279DOI: (10.5555/uri:pii:S0022522394704813) Copyright © 1994 Mosby, Inc. Terms and Conditions