Apical membrane handling of substances, in this example aminoglycosides, by proximal tubular cells. Apical membrane handling of substances, in this example.

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Presentation transcript:

Apical membrane handling of substances, in this example aminoglycosides, by proximal tubular cells. Apical membrane handling of substances, in this example aminoglycosides, by proximal tubular cells. Aminoglycosides interact with anionic phospholipids/megalin on the apical surface where they are endocytosed and enter the cell. The drug is then translocated into lysosomes, where it is associated with various forms of cellular injury. Abbreviations: AG (+), aminoglycoside; (-) PL, anionic phospholipids; M, megalin; Lys, lysosome; Na+, sodium; K+, potassium. Mark A. Perazella CJASN 2009;4:1275-1283 ©2009 by American Society of Nephrology