Tumoral presence of human cytomegalovirus is associated with shorter disease-free survival in elderly patients with colorectal cancer and higher levels.

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Tumoral presence of human cytomegalovirus is associated with shorter disease-free survival in elderly patients with colorectal cancer and higher levels of intratumoral interleukin-17 H.-P. Chen, J.-K. Jiang, P.-Y. Lai, C.-Y. Chen, T.-Y. Chou, Y.-C. Chen, C.-H. Chan, S.-F. Lin, C.-Y. Yang, C.-Y. Chen, C.-H. Lin, J.-K. Lin, D.M.-T. Ho, W.-L. Cho, Y.-J. Chan Clinical Microbiology and Infection Volume 20, Issue 7, Pages 664-671 (July 2014) DOI: 10.1111/1469-0691.12412 Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Distribution of human cytomegalovirus (HCMV)-positive and HCMV-negative tumours according to (a) age quartiles and (b) tumour stages. The average patient ages in the three younger quartiles and oldest quartile were 73.6 ± 4.3 years and 83.9 ± 3.8 years, respectively. For distribution according to tumour stage, the data of the elderly patients with colorectal cancer who underwent curative surgery were analysed. Clinical Microbiology and Infection 2014 20, 664-671DOI: (10.1111/1469-0691.12412) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Kaplan–Meier curves of disease-free survival. (a) Patients with colorectal cancer who underwent curative surgery (n = 81). (b) Patients without distant metastasis (stage I-III tumours) at the time of surgery (n = 71). HCMV, human cytomegalovirus. Clinical Microbiology and Infection 2014 20, 664-671DOI: (10.1111/1469-0691.12412) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 3 Kaplan–Meier curves of disease-free survival. (a) All patients stratified according to tumour stage. (b) Patients with stage I and IV tumours stratified according to the tumoral presence of human cytomegalovirus (HCMV). (c, d) Patients with stage II and III tumours stratified according to the tumoral presence of HCMV. ns, not significant. Clinical Microbiology and Infection 2014 20, 664-671DOI: (10.1111/1469-0691.12412) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 4 Results of the multivariate hazard ratio analysis of 5-year disease recurrence. Factors influencing the outcome of colorectal cancer were analysed. CEA, carcinoembryonic antigen; HCMV, human cytomegalovirus. Clinical Microbiology and Infection 2014 20, 664-671DOI: (10.1111/1469-0691.12412) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 5 Relative gene expression levels of major cytokines and signal transducers of T-cell subsets in human cytomegalovirus (HCMV)-positive tumours (n = 5) and HCMV-negative tumours (n = 5). The relative expression level of each gene was normalized by the median level in the HCMV-negative tumours. IFN, interferon; IL, interleukin; IL17RC, IL-17 receptor C; STAT, signal transducer and activator of transcription; TNF, tumour necrosis factor. Clinical Microbiology and Infection 2014 20, 664-671DOI: (10.1111/1469-0691.12412) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions