A Unified Sampling Approach for Multipoint Analysis of Qualitative and Quantitative Traits in Sib Pairs Kung-Yee Liang, Chiung-Yu Huang, Terri H. Beaty

Slides:

Advertisements

Similar presentations

Nuclear and Mitochondrial DNA Analysis of a 2,000-Year-Old Necropolis in the Egyin Gol Valley of Mongolia Christine Keyser-Tracqui, Eric Crubézy, Bertrand.

Advertisements

Previous Estimates of Mitochondrial DNA Mutation Level Variance Did Not Account for Sampling Error: Comparing the mtDNA Genetic Bottleneck in Mice and.

Connexin Mutations in Skin Disease and Hearing Loss David P. Kelsell, Wei-Li Di, Mark J. Houseman The American Journal of Human Genetics Volume 68, Issue.

Functional Analysis of the Neurofibromatosis Type 2 Protein by Means of Disease- Causing Point Mutations Renee P. Stokowski, David R. Cox The American.

Gene Preference in Maple Syrup Urine Disease Mary M. Nellis, Dean J. Danner The American Journal of Human Genetics Volume 68, Issue 1, Pages (January.

A Multilocus Model of the Genetic Architecture of Autoimmune Thyroid Disorder, with Clinical Implications Veronica J. Vieland, Yungui Huang, Christopher.

Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part I: Methods and Power Analysis Douglas F. Levinson, Matthew D. Levinson, Ricardo Segurado,

Genomewide Comparison of DNA Sequences between Humans and Chimpanzees Ingo Ebersberger, Dirk Metzler, Carsten Schwarz, Svante Pääbo The American Journal.

Fragile X and X-Linked Intellectual Disability: Four Decades of Discovery Herbert A. Lubs, Roger E. Stevenson, Charles E. Schwartz The American Journal.

Effects of Milk Powders in Milk Chocolate B. Liang, R.W. Hartel Journal of Dairy Science Volume 87, Issue 1, Pages (January 2004) DOI: /jds.S (04)

The Duty to Recontact: Attitudes of Genetics Service Providers Jennifer L. Fitzpatrick, Cecil Hahn, Teresa Costa, Marlene J. Huggins The American Journal.

Peopling of Sahul: mtDNA Variation in Aboriginal Australian and Papua New Guinean Populations Alan J. Redd, Mark Stoneking The American Journal of Human.

National Guidelines for Nursing Delegation

The Trimmed-Haplotype Test for Linkage Disequilibrium

Air Pollution and Chest Disease

Anna Middleton, J. Hewison, R.F. Mueller

Quantitative-Trait Loci Influencing Body-Mass Index Reside on Chromosomes 7 and 13: The National Heart, Lung, and Blood Institute Family Heart Study

Transmission/Disequilibrium Tests for Extended Marker Haplotypes

Anna Middleton, J. Hewison, R.F. Mueller

Daniel J. Schaid, Charles M. Rowland, David E. Tines, Robert M

Robustness and Power of the Maximum-Likelihood–Binomial and Maximum-Likelihood– Score Methods, in Multipoint Linkage Analysis of Affected-Sibship Data

Terry L. Jue, MD Gastrointestinal Endoscopy

Genetic Linkage Analysis of a Dichotomous Trait Incorporating a Tightly Linked Quantitative Trait in Affected Sib Pairs Jian Huang, Yanming Jiang The.

CHEK2*1100delC and Susceptibility to Breast Cancer: A Collaborative Analysis Involving 10,860 Breast Cancer Cases and 9,065 Controls from 10 Studies

2016 Curt Stern Award Address: From Rare to Common Diseases: Translating Genetic Discovery to Therapy1 Brendan Lee The American Journal of Human Genetics

Quantitative-Trait Loci Influencing Body-Mass Index Reside on Chromosomes 7 and 13: The National Heart, Lung, and Blood Institute Family Heart Study

A Whole-Genome Scan in 164 Dutch Sib Pairs with Attention-Deficit/Hyperactivity Disorder: Suggestive Evidence for Linkage on Chromosomes 7p and 15q S.C.

Yu Jiang, Glen A. Satten, Yujun Han, Michael P. Epstein, Erin L

Meta-analysis of Genetic-Linkage Analysis of Quantitative-Trait Loci

Linkage Thresholds for Two-stage Genome Scans

Genetics, Individuality, and Medicine in the 21st Century*

The American Journal of Human Genetics

Bias in Estimates of Quantitative-Trait–Locus Effect in Genome Scans: Demonstration of the Phenomenon and a Method-of-Moments Procedure for Reducing Bias

GeneTests: Integrating Genetic Services into Patient Care*

Family-Based Association Studies for Next-Generation Sequencing

Five Years of GWAS Discovery

Stephen C. Pratt, Mark J. Daly, Leonid Kruglyak

Johanna Jakobsdottir, Mary Sara McPeek

E. Warwick Daw, Simon C. Heath, Ellen M. Wijsman

Dan-Yu Lin, Zheng-Zheng Tang The American Journal of Human Genetics

The SNP Endgame: A Multidisciplinary Approach*

Family-Based Tests of Association in the Presence of Linkage

Erratum The American Journal of Human Genetics

A Genomewide Linkage Scan for Quantitative-Trait Loci for Obesity Phenotypes Hong-Wen Deng, Hongyi Deng, Yong-Jun Liu, Yao-Zhong Liu, Fu-Hua Xu, Hui Shen,

William F. Forrest, Eleanor Feingold

Michael P. Epstein, Xihong Lin, Michael Boehnke

Volume 69, Issue 12, Pages (June 2006)

Volume 69, Issue 3, Pages (February 2006)

Nonpaternity in Linkage Studies of Extremely Discordant Sib Pairs

David B. Allison, Bonnie Thiel, Pamela St. Jean, Robert C

Suzanne M. Leal, Jurg Ott The American Journal of Human Genetics

674. Molecular, Biochemical and Biomechanical Analysis of Articular Cartilage Repaired with Genetically Modified Chondrocytes Expressing Insulin-Like.

Increasing the Power and Efficiency of Disease-Marker Case-Control Association Studies through Use of Allele-Sharing Information Tasha E. Fingerlin,

Society for Investigative Dermatology 2010 Meeting Minutes

Greg L. Loeben, Theresa M. Marteau, Benjamin S. Wilfond

L-GATOR: Genetic Association Testing for a Longitudinally Measured Quantitative Trait in Samples with Related Individuals Xiaowei Wu, Mary Sara McPeek

Table of contents The Journal for Nurse Practitioners

Journal of Investigative Dermatology

Discussion The Journal of Thoracic and Cardiovascular Surgery

Direct Observation of Residents: A Model for an Assessment System

Iuliana Ionita-Laza, Seunggeun Lee, Vlad Makarov, Joseph D

A Quantitative-Trait Locus on Chromosome 6p Influences Different Aspects of Developmental Dyslexia Simon E. Fisher, Angela J. Marlow, Janine Lamb, Elena.

Alice S. Whittemore, Jerry Halpern

Genetic Linkage Analysis of a Dichotomous Trait Incorporating a Tightly Linked Quantitative Trait in Affected Sib Pairs Jian Huang, Yanming Jiang The.

Anna Middleton, J. Hewison, R.F. Mueller

Quiz page December 2003 American Journal of Kidney Diseases

Sanjay Shete, Xiaojun Zhou, Christopher I. Amos

Kung-Yee Liang, Fang-Chi Hsu, Terri H. Beaty, Kathleen C. Barnes

B. Yuan, R. Neuman, S. H. Duan, J. L. Weber, P. Y. Kwok, N. L

The Size Distribution of Homozygous Segments in the Human Genome

Presentation transcript:

A Unified Sampling Approach for Multipoint Analysis of Qualitative and Quantitative Traits in Sib Pairs Kung-Yee Liang, Chiung-Yu Huang, Terri H. Beaty The American Journal of Human Genetics Volume 66, Issue 5, Pages 1631-1641 (May 2000) DOI: 10.1086/302900 Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 1 Ratio of asymptotic var ( τ^) for designs II–IV versus design I for τ, the true QTL, 0≤τ≤100 cM The American Journal of Human Genetics 2000 66, 1631-1641DOI: (10.1086/302900) Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 2 Asymptotic variance of τ^ versus τ, the true QTL, 0≤τ≤20 cM for designs I–III. The assumed model is an additive model, with p=.2 and ρ=.0. The American Journal of Human Genetics 2000 66, 1631-1641DOI: (10.1086/302900) Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 3 V1/V2 ratio versus log[λ1/(1-λ1)]. Here, λ1 is the proportion of ED sib pairs among ED and EC sib pairs The American Journal of Human Genetics 2000 66, 1631-1641DOI: (10.1086/302900) Copyright © 2000 The American Society of Human Genetics Terms and Conditions