Hemoglobin-based oxygen carrier HBOC-201 provides higher and faster increase in oxygen tension in skeletal muscle of anemic dogs than do stored red blood.

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Presentation transcript:

Hemoglobin-based oxygen carrier HBOC-201 provides higher and faster increase in oxygen tension in skeletal muscle of anemic dogs than do stored red blood cells Th. Standl, MD, M. Freitag, MD, M.A. Burmeister, MD, E.P. Horn, MD, S. Wilhelm, MD, J.Schulte am Esch, MD Journal of Vascular Surgery Volume 37, Issue 4, Pages 859-865 (April 2003) DOI: 10.1067/mva.2003.127 Copyright © 2003 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 1 Changes in muscular oxygen extraction ratio (ERo2) during decrease and increase in global hemoglobin concentration with HBOC-201 or RBCs. Values are expressed as mean ± SEM. *P <.05; **P <.01; ***P <.001 compared with baseline; #P <.05; ##P <.01 compared with RBC group. Journal of Vascular Surgery 2003 37, 859-865DOI: (10.1067/mva.2003.127) Copyright © 2003 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 2 Observed and predicted values (dotted lines) of skeletal muscle tPO2 at the 10th, 50th , and 90th percentiles during decrease and increase in global hemoglobin concentration with HBOC-201 or RBCs. *P <.05; **P <.01; ***P <.001 compared with baseline; # P <.05; ## P <.01 compared with RBC group; + P <.05; ++ P <.01; +++ P <.001 compared with T1. Journal of Vascular Surgery 2003 37, 859-865DOI: (10.1067/mva.2003.127) Copyright © 2003 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions